van der Merwe Marie, Moore Damien, Hill Jessica L, Keating Faith H, Buddington Randal K, Bloomer Richard J, Wang Anyou, Bowman Dale D
Center for Nutraceuticals and Dietary Supplement Research, College of Health Sciences, University of Memphis, 106 Elma Roane Fieldhouse, Zach Curlin Rd., Memphis, TN 38152, USA.
Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN 38152, USA.
Microorganisms. 2021 Apr 14;9(4):843. doi: 10.3390/microorganisms9040843.
Phytochemicals from fruits and vegetables are known to reduce inflammation and improve overall health. The objective of this study was to determine the effect of a fruit and vegetable concentrate (FVC) and high fiber component on the gut microbiome in an overweight/obese, female population. The study was a randomized, double blind, placebo-controlled trial with 57 asymptomatic, pre-menopausal, overweight/obese females between 25-50 years of age working in healthcare. Blood and fecal samples were collected before and after two, four and five months of daily supplementation. Metabolic parameters were measured, and the gut microbiome analyzed. No effect was observed with FVC supplementation for blood lipids, glucose and immune parameters. There was an improvement in glucose clearance. The FVC supplement did not result in taxonomic alterations at phyla level, or changes in α or β diversity, but reduced Bacteroides abundance and increased fecal butyrate. An additional high fiber component improved levels of health associated bacteria. The results suggest that a dried fruit and vegetable supplement, with a high fiber meal replacement can alter the intestinal microbiota and improve glucose clearance, suggesting that this combination of supplements can improve glucose metabolism and possibly reduce the risk of insulin resistance.
已知水果和蔬菜中的植物化学物质可减轻炎症并改善整体健康状况。本研究的目的是确定水果和蔬菜浓缩物（FVC）以及高纤维成分对超重/肥胖女性群体肠道微生物群的影响。该研究是一项随机、双盲、安慰剂对照试验，共有57名年龄在25至50岁之间、无症状、处于绝经前、超重/肥胖的女性医护人员参与。在每日补充剂服用两个月、四个月和五个月前后采集血液和粪便样本。测量代谢参数并分析肠道微生物群。补充FVC对血脂、血糖和免疫参数未观察到影响。葡萄糖清除率有所改善。FVC补充剂未导致门水平的分类学改变，也未引起α或β多样性的变化，但降低了拟杆菌丰度并增加了粪便丁酸盐含量。额外的高纤维成分改善了与健康相关细菌的水平。结果表明，一种含有高纤维代餐的水果和蔬菜干补充剂可改变肠道微生物群并改善葡萄糖清除率，这表明这种补充剂组合可改善葡萄糖代谢并可能降低胰岛素抵抗风险。
