口腔鳞状细胞癌基质细胞和肿瘤细胞中雄激素受体、血管内皮生长因子、缺氧诱导因子-1、Ki67和基质金属蛋白酶9在非转移期与转移期表达的比较
Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma.
作者信息
Batelja-Vuletic Lovorka, Tomasovic-Loncaric Cedna, Ceppi Marcello, Bruzzone Marco, Fucic Aleksandra, Krstanac Karolina, Boras Vucicevic Vanja
机构信息
Medical School, Zagreb, University of Zagreb, 10000 Zagreb, Croatia.
Clinical Hospital Centre Dubrava, 10000 Zagreb, Croatia.
出版信息
Life (Basel). 2021 Apr 10;11(4):336. doi: 10.3390/life11040336.
OBJECTIVES
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy with low survival as it is very often diagnosed at an advanced stage, which is why the accurate profiling of the tumor is essential. The aim of this study was to, for the first time, compare in OSCC the frequency of AR, VEGF, MMP9, HiF1beta and Ki67 between the non-metastatic and metastatic disease.
MATERIALS AND METHODS
In the study, 96 non-metastatic and 91 metastatic OSCC patients were analysed for AR, VEGF, MMP9, HiF1beta and Ki67 levels by immunohistochemistry.
RESULTS
All of the tested biomarkers significantly differed between non-metastatic and metastatic disease. A significant association was found between >/=20% AR positive epithelium cells in cytoplasm, Ki67 and VEGF in cancer stroma. Ki67, HiF1beta, VEGF and MMP9 were significantly associated with TNM stages.
CONCLUSION
Our results show for the first time an interplay between AR, VEGF, MMP9, HiF1beta and Ki67 in OSCC which may contribute to better diagnostics and therapy selection.
目的
口腔鳞状细胞癌（OSCC）是最常见的口腔恶性肿瘤，由于其常常在晚期才被诊断出来，生存率较低，这就是为何对肿瘤进行准确的特征分析至关重要。本研究的目的是首次比较非转移性和转移性口腔鳞状细胞癌中雄激素受体（AR）、血管内皮生长因子（VEGF）、基质金属蛋白酶9（MMP9）、低氧诱导因子1β（HiF1β）和Ki67的表达频率。
材料与方法
在本研究中，通过免疫组织化学分析了96例非转移性和91例转移性口腔鳞状细胞癌患者的AR、VEGF、MMP9、HiF1β和Ki67水平。
结果
所有检测的生物标志物在非转移性和转移性疾病之间均有显著差异。在细胞质中AR阳性上皮细胞≥20%、癌基质中的Ki67和VEGF之间发现了显著关联。Ki67、HiF1β、VEGF和MMP9与TNM分期显著相关。
结论
我们的结果首次表明在口腔鳞状细胞癌中AR、VEGF、MMP9, HiF1β和Ki67之间存在相互作用，这可能有助于更好的诊断和治疗选择。
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