Faculty of Odontology, Rey Juan Carlos University, Avenida de Atenas s/n, 28922 Alcorcón, Madrid (Spain),
Med Oral Patol Oral Cir Bucal. 2019 Sep 1;24(5):e603-e609. doi: 10.4317/medoral.23011.
More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue. Classically, this disease has affected men preferentially, although recent studies suggest that trends are changing and the proportion of women with OSCC is increasing. In addition, the prevalence of oral cancer is also determined by some risk factors as alcohol consumption and tobacco. Currently, the Tumor, Node, Metastasis (TNM) classification is employed to defined tumor stage and based on this guide specific treatments are established. However, 5-year-survival does not exceed 50% of cases. The objective of this study is to determine whether a histological risk pattern indicative of higher recurrence might be present in T1-T2 tumors located in the anterior two thirds of the tongue.
Samples from 26 patients with OSCC were analyzed and histological risk pattern of recurrent and non-recurrent tumors were compared. We have analyzed histological variables described in Anneroth and Brandwein-Gensler classifications. Additionally, we have also examined both clinical variables such as age, sex or comorbidities, as well as habits such as tobacco or alcohol consumption.
We found that sex (male) and keratinization degree (high or moderate) are directly related with OSCC recurrence. In fact, free illness time is lower in men and higher in those cases with minimal or no keratinization.
Based on the variables analyzed, it has not been possible to establish a histological risk pattern that, complementary to the TNM classification, could have a predictive role in these early-stage tongue carcinomas.
超过 90%在口腔中诊断出的恶性肿瘤为口腔鳞状细胞癌（OSCC），其首选位置是舌头。经典地，这种疾病更常影响男性，尽管最近的研究表明趋势正在改变，并且 OSCC 女性的比例正在增加。此外，口腔癌的患病率还取决于一些风险因素，如饮酒和吸烟。目前，采用肿瘤、淋巴结、转移（TNM）分类来定义肿瘤分期，并根据该指南制定特定的治疗方法。然而，5 年生存率不超过 50%的病例。本研究的目的是确定位于舌头前 2/3 部分的 T1-T2 肿瘤是否存在提示更高复发风险的组织学风险模式。
分析了 26 例 OSCC 患者的样本，并比较了复发性和非复发性肿瘤的组织学风险模式。我们分析了 Anneroth 和 Brandwein-Gensler 分类中描述的组织学变量。此外，我们还检查了年龄、性别或合并症等临床变量，以及吸烟或饮酒等习惯。
我们发现性别（男性）和角化程度（高或中）与 OSCC 复发直接相关。事实上，男性的无病时间较短，角化程度最低或无角化的患者无病时间较高。
根据分析的变量，尚未建立一种组织学风险模式，该模式可以与 TNM 分类相结合，对这些早期舌癌具有预测作用。
