生物合成氧化铜纳米粒子的抗菌和抗癌活性。
Antibacterial and anticancer activity of biosynthesised CuO nanoparticles.
机构信息
Department of Chemistry, Nanoscience Research Laboratory, KSMDB College, Research Centre, University of Kerala, Sasthamcotta, Kollam, Kerala, India.
出版信息
IET Nanobiotechnol. 2020 Dec;14(9):833-838. doi: 10.1049/iet-nbt.2020.0088.
Abstract
The present investigation aims for the synthesis of copper oxide nanoparticles (CuO NPs) using plant extract. The obtained CuO NPs were characterised by X-ray diffraction, Fourier transform infrared spectrum, ultraviolet-visible spectroscopy, photoluminescence, scanning electron microscopy and transmission electron microscopy analysis. Significant bacterial activity was manifested by CuO nanoparticles against both Gram-positive ( and ) and Gram-negative ( and ) bacteria. The synthesised CuO NPs have good cytotoxicity against both human breast cancer cell line (MCF-7) and lung cancer cell line (A549) with minimum cytotoxic effect on normal L929 (fibroblast) cell lines.
摘要
本研究旨在利用植物提取物合成氧化铜纳米粒子（CuO NPs）。通过 X 射线衍射、傅里叶变换红外光谱、紫外-可见光谱、光致发光、扫描电子显微镜和透射电子显微镜分析对所得 CuO NPs 进行了表征。氧化铜纳米粒子对革兰氏阳性菌（ 和 ）和革兰氏阴性菌（ 和 ）均表现出显著的抗菌活性。所合成的 CuO NPs 对人乳腺癌细胞系（MCF-7）和肺癌细胞系（A549）均具有良好的细胞毒性，对正常 L929（成纤维细胞）细胞系的细胞毒性最小。
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