Verma Nishant, Kumar Nikhil
National Centre for Flexible Electronics, Indian Institute of Technology, Kanpur, Kalyanpur, Kanpur, Uttar Pradesh-208016, India.
Department of Biotechnology, National Institute of Technology, Raipur, G.E. Road, Opposite Science College, Raipur, Chhattisgarh-492010, India.
ACS Biomater Sci Eng. 2019 Mar 11;5(3):1170-1188. doi: 10.1021/acsbiomaterials.8b01092. Epub 2019 Feb 21.
Synthesis of copper oxide nanoparticles with tunable size and desirable properties is a foremost thrust area of the biomedical research domain. Though these features primarily rely on the synthetic approaches involved, with advancements in this area, it has been documented that the synthesis parameters and surface modifiers have a direct impact on the morphology and eventually on the biomedical properties. "Sensing" remains a major application of nanomaterials owing to their small size and unusual physicochemical properties, but in the past few years, a paradigm shift has occurred toward "theranostic" combination of the sensing and therapeutic features on a single platform. Copper oxide nanoparticles have been efficiently used for sensing and targeting in both and environments, although few key challenges are yet to be resolved before implementing at a commercial level. This review article attempts to summarize the recent advancements in the various synthetic approaches toward copper oxide nanoparticles and their biomedical applications. It highlights various synthetic methodologies including electrochemical, chemical, and biogenic methods, the role of surface modifiers in growth mechanisms, and their impact on biomedical applications. Finally, the current status, key challenges, and future perspective of copper oxide nanoparticles will be discussed that inevitably have an impact on their current and future scenarios.
合成具有可调节尺寸和理想性能的氧化铜纳米颗粒是生物医学研究领域的一个首要重点领域。尽管这些特性主要依赖于所涉及的合成方法，但随着该领域的进展，已有文献记载合成参数和表面改性剂对形态有直接影响，并最终影响生物医学性能。由于其尺寸小和不寻常的物理化学性质，“传感”仍然是纳米材料的一个主要应用，但在过去几年中，已经出现了一种范式转变，即朝着在单一平台上实现传感和治疗功能的“诊疗一体化”组合发展。氧化铜纳米颗粒已被有效地用于体内和体外环境中的传感和靶向，尽管在商业层面实施之前仍有一些关键挑战有待解决。这篇综述文章试图总结在合成氧化铜纳米颗粒的各种方法及其生物医学应用方面的最新进展。它重点介绍了包括电化学、化学和生物方法在内的各种合成方法、表面改性剂在生长机制中的作用以及它们对生物医学应用的影响。最后，将讨论氧化铜纳米颗粒的现状、关键挑战和未来前景，这些不可避免地会对它们的当前和未来情况产生影响。
