Candel-Parra Eduardo, Córcoles-Jiménez María Pilar, Delicado-Useros Victoria, Hernández-Martínez Antonio, Molina-Alarcón Milagros
Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, Av. de España, 02001 Albacete, Spain.
Department of Nursing, Physiotherapy and Occupational Therapy, Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.
J Clin Med. 2021 Apr 22;10(9):1824. doi: 10.3390/jcm10091824.
Parkinson's disease (PD) is a chronic neurodegenerative disorder that results in important functional symptoms, altered mood, and deterioration in quality of life (QoL). This study aimed to determine the evolution of the QoL in persons with PD in the Albacete health district over a two-year period and identify associated sociodemographic, clinical, and socio-health characteristics. A cohort study was conducted of patients at different stages of PD in the Albacete health district. Calculated sample size: 155 patients. Instruments: A purpose-designed questionnaire for data collection and the "Parkinson Disease Questionnaire" (PDQ-39), which measures 8 dimensions and a global index where a higher score indicates worse quality of life. Three measurements were made: baseline, one year, two years. A descriptive and bivariate analysis was conducted. Ethical aspects: informed consent, anonymized data. Results: Mean age 69.51 (standard deviation, SD 8.73) years, 60% male, 75.5% married, and 85.5% lived with family. The most frequent motor symptoms were slow movement (86.23%), postural instability (55.5%), tremor (45.5%), and dyskinesia (24.6%). Among the non-motor symptoms were fatigue (66.2%), pain, daytime somnolence, constipation, and apathy, with approximately 50% each. The mean QoL score at baseline was 27.47 (SD 16.14); 95% CI (confidence interval) 24.91-30.03. At two years, global QoL had slightly worsened (28.3; SD 17.26; 95% CI 25.41-31.18), with a statistically significant worsening in mobility, activities of daily living, and communication, whereas social support improved.
帕金森病（PD）是一种慢性神经退行性疾病，会导致重要的功能症状、情绪改变以及生活质量（QoL）下降。本研究旨在确定阿尔巴塞特健康区帕金森病患者在两年期间生活质量的变化情况，并识别相关的社会人口学、临床和社会健康特征。对阿尔巴塞特健康区不同阶段帕金森病患者进行了一项队列研究。计算得出的样本量为155名患者。研究工具：一份专门设计的数据收集问卷和“帕金森病问卷”（PDQ - 39），该问卷测量8个维度和一个综合指数，得分越高表明生活质量越差。进行了三次测量：基线、一年、两年。进行了描述性和双变量分析。伦理方面：知情同意，数据匿名化。结果：平均年龄69.51岁（标准差，SD 8.73），男性占60%，已婚占75.5%，85.5%与家人同住。最常见的运动症状为运动迟缓（86.23%）、姿势不稳（55.5%）、震颤（45.5%）和异动症（24.6%）。非运动症状包括疲劳（66.2%）、疼痛、日间嗜睡、便秘和冷漠，各约占50%。基线时生活质量平均得分为27.47（SD 16.14）；95%置信区间（CI）为24.91 - 30.03。两年时，总体生活质量略有恶化（28.3；SD 17.26；95% CI 25.41 - 31.18），其中运动能力、日常生活活动和沟通方面有统计学意义的恶化，而社会支持有所改善。
