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用于测定药物制剂中阿片类药物盐酸曲马多的先进功能化CeO/AlO纳米复合传感器。

Advanced Functionalized CeO/AlO Nanocomposite Sensor for Determination of Opioid Medication Tramadol Hydrochloride in Pharmaceutical Formulations.

作者信息

Alterary Seham S, El-Tohamy Maha F

机构信息

Department of Chemistry, College of Science, King Saud University, P.O. Box 50013, Riyadh 11523, Saudi Arabia.

出版信息

Nanomaterials (Basel). 2022 Apr 16;12(8):1373. doi: 10.3390/nano12081373.

DOI:10.3390/nano12081373
PMID:35458081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9025318/
Abstract

BACKGROUND

The exceptional characteristics of cerium oxide (CeO) and aluminum oxide (AlO) nanoscales have inspired significant attention to those nanocomposites as possible electroactive resources for applications of sensing and biosensing.

METHODS

In this research, an innovative new factionalized CeO/AlO nanocomposite membrane sensor was presented to assess tramadol hydrochloride (TRD) in marketable products.

RESULTS

Tramadol-phosphomolybdate (TRD-PM) was formed by mixing tramadol hydrochloride and phosphomolybdic acid (PMA) in the attendance of polymeric matrix and -nitrophenyloctyl ether solvent mediator. With 1.0 × 10-1.0 × 10 mol L as a range of linearity and E = (57.567 ± 0.2) log [TRD] + 676.29 as a regression equation, the functionalized sensor using TRD-PM-CeO/AlO nanocomposite showed great selectivity and sensitivity for the discriminating and measurement of TRD. Using the regression equation E = (52.143 ± 0.4) log [TRD] + 431.45, the unmodified coated wire sensor of TRD-PM, on the other hand, showed a Nernstian response between 1.0 × 10 and 1.0 × 10 mol L, Using the methodology's specified guidelines, the proposed improved potentiometric system was validated against several criteria.

CONCLUSION

The suggested method is suitable for the determination of TRD in its products.

摘要

背景

氧化铈（CeO）和氧化铝（AlO）纳米尺度的特殊特性激发了人们对这些纳米复合材料作为传感和生物传感应用中可能的电活性资源的极大关注。

方法

在本研究中，提出了一种创新的新型分段CeO/AlO纳米复合膜传感器，用于评估市售产品中的盐酸曲马多（TRD）。

结果

在聚合物基质和对硝基苯基辛基醚溶剂介质存在下，将盐酸曲马多与磷钼酸（PMA）混合形成曲马多 - 磷钼酸盐（TRD - PM）。以1.0×10⁻¹.⁰×10⁻⁶mol/L为线性范围，E = (57.567 ± 0.2) log [TRD] + 676.29为回归方程，使用TRD - PM - CeO/AlO纳米复合材料的功能化传感器对TRD的鉴别和测量显示出极大的选择性和灵敏度。另一方面，使用回归方程E = (52.143 ± 0.4) log [TRD] + 431.45，TRD - PM的未修饰涂丝传感器在1.0×10⁻⁶和1.0×10⁻¹mol/L之间显示出能斯特响应，按照该方法指定的指南，所提出改进的电位测定系统针对多个标准进行了验证。

结论

所建议的方法适用于其产品中TRD的测定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/92e597e92966/nanomaterials-12-01373-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/1b971c010044/nanomaterials-12-01373-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/737d75764a78/nanomaterials-12-01373-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/3540459a7976/nanomaterials-12-01373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/ca5386a78260/nanomaterials-12-01373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/09a23bfa9d0a/nanomaterials-12-01373-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/92e597e92966/nanomaterials-12-01373-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/1b971c010044/nanomaterials-12-01373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/3056f0dcdbc4/nanomaterials-12-01373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/570169a3ea87/nanomaterials-12-01373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/67f68ba36081/nanomaterials-12-01373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/569206e7954a/nanomaterials-12-01373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/7f2df3cbdb2f/nanomaterials-12-01373-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/737d75764a78/nanomaterials-12-01373-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/3540459a7976/nanomaterials-12-01373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/ca5386a78260/nanomaterials-12-01373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/09a23bfa9d0a/nanomaterials-12-01373-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c850/9025318/92e597e92966/nanomaterials-12-01373-g011.jpg

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