Advanced Functionalized CeO/AlO Nanocomposite Sensor for Determination of Opioid Medication Tramadol Hydrochloride in Pharmaceutical Formulations.

BACKGROUND

The exceptional characteristics of cerium oxide (CeO) and aluminum oxide (AlO) nanoscales have inspired significant attention to those nanocomposites as possible electroactive resources for applications of sensing and biosensing.

METHODS

In this research, an innovative new factionalized CeO/AlO nanocomposite membrane sensor was presented to assess tramadol hydrochloride (TRD) in marketable products.

RESULTS

Tramadol-phosphomolybdate (TRD-PM) was formed by mixing tramadol hydrochloride and phosphomolybdic acid (PMA) in the attendance of polymeric matrix and -nitrophenyloctyl ether solvent mediator. With 1.0 × 10-1.0 × 10 mol L as a range of linearity and E = (57.567 ± 0.2) log [TRD] + 676.29 as a regression equation, the functionalized sensor using TRD-PM-CeO/AlO nanocomposite showed great selectivity and sensitivity for the discriminating and measurement of TRD. Using the regression equation E = (52.143 ± 0.4) log [TRD] + 431.45, the unmodified coated wire sensor of TRD-PM, on the other hand, showed a Nernstian response between 1.0 × 10 and 1.0 × 10 mol L, Using the methodology's specified guidelines, the proposed improved potentiometric system was validated against several criteria.

CONCLUSION

The suggested method is suitable for the determination of TRD in its products.