International Chair of Sport Medicine, Faculty of Medicine, Campus de los Jerónimos, Catholic University of Murcia, 30107 Murcia, Spain.
Faculty of Sport, Campus de los Jerónimos, Catholic University of Murcia, 30107 Murcia, Spain.
Nutrients. 2021 Apr 16;13(4):1321. doi: 10.3390/nu13041321.
The main objective of this research was to carry out an experimental study, triple-blind, on the possible immunophysiological effects of a nutritional supplement (synbiotic, Gasteel Plus, Heel España S.A.U.), containing a mixture of probiotic strains, such as CBP-001010, CNCM I-4036, and ES1, as well as the prebiotic fructooligosaccharides, on both professional athletes and sedentary people. The effects on some inflammatory/immune (IL-1β, IL-10, and immunoglobulin A) and stress (epinephrine, norepinephrine, dopamine, serotonin, corticotropin-releasing hormone (CRH), Adrenocorticotropic hormone (ACTH), and cortisol) biomarkers were evaluated, determined by flow cytometer and ELISA. The effects on metabolic profile and physical activity, as well as on various parameters that could affect physical and mental health, were also evaluated via the use of accelerometry and validated questionnaires. The participants were professional soccer players in the Second Division B of the Spanish League and sedentary students of the same sex and age range. Both study groups were randomly divided into two groups: a control group-administered with placebo, and an experimental group-administered with the synbiotic. Each participant was evaluated at baseline, as well as after the intervention, which lasted one month. Only in the athlete group did the synbiotic intervention clearly improve objective physical activity and sleep quality, as well as perceived general health, stress, and anxiety levels. Furthermore, the synbiotic induced an immunophysiological bioregulatory effect, depending on the basal situation of each experimental group, particularly in the systemic levels of IL-1β (increased significantly only in the sedentary group), CRH (decreased significantly only in the sedentary group), and dopamine (increased significantly only in the athlete group). There were no significant differences between groups in the levels of immunoglobulin A or in the metabolic profile as a result of the intervention. It is concluded that synbiotic nutritional supplements can improve anxiety, stress, and sleep quality, particularly in sportspeople, which appears to be linked to an improved immuno-neuroendocrine response in which IL-1β, CRH, and dopamine are clearly involved.
本研究的主要目的是进行一项实验研究，即对一种营养补充剂（共生元，Gasteel Plus，Heel España S.A.U.）的可能免疫生理学效应进行三重盲法研究，该补充剂含有益生菌菌株混合物，如 CBP-001010、CNCM I-4036 和 ES1，以及益生元果寡糖，研究对象为职业运动员和久坐不动的人。通过流式细胞仪和 ELISA 测定法评估了对某些炎症/免疫（IL-1β、IL-10 和免疫球蛋白 A）和应激（肾上腺素、去甲肾上腺素、多巴胺、血清素、促肾上腺皮质释放激素（CRH）、促肾上腺皮质激素（ACTH）和皮质醇）生物标志物的影响。还通过使用加速度计和经过验证的问卷评估了对代谢谱和身体活动以及对可能影响身心健康的各种参数的影响。参与者为西班牙乙级联赛的职业足球运动员和同性别、年龄相仿的久坐不动的学生。两组研究对象均随机分为两组：对照组给予安慰剂，实验组给予共生元。每个参与者在基线时以及干预后（持续一个月）接受评估。只有在运动员组中，共生元干预明显改善了客观身体活动和睡眠质量，以及感知到的整体健康、应激和焦虑水平。此外，共生元根据每个实验组的基础情况诱导了免疫生理生物调节效应，特别是在系统性的 IL-1β 水平（久坐不动组显著增加）、CRH（久坐不动组显著降低）和多巴胺（运动员组显著增加）水平。干预后，免疫球蛋白 A 水平或代谢谱在组间没有差异。结论是，共生元营养补充剂可以改善焦虑、应激和睡眠质量，特别是在运动员中，这似乎与免疫神经内分泌反应的改善有关，其中 IL-1β、CRH 和多巴胺显然参与其中。
