Guilherme Malena Dos Santos, Nguyen Vu Thu Thuy, Reinhardt Christoph, Endres Kristina
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Microorganisms. 2021 Apr 13;9(4):815. doi: 10.3390/microorganisms9040815.
The gut brain axis seems to modulate various psychiatric and neurological disorders such as Alzheimer's disease (AD). Growing evidence has led to the assumption that the gut microbiome might contribute to or even present the nucleus of origin for these diseases. In this regard, modifiers of the microbial composition might provide attractive new therapeutics. Aim of our study was to elucidate the effect of a rigorously changed gut microbiome on pathological hallmarks of AD. 5xFAD model mice were treated by antibiotics or probiotics ( and ) for 14 weeks. Pathogenesis was measured by nest building capability and plaque deposition. The gut microbiome was affected as expected: antibiotics significantly reduced viable commensals, while probiotics transiently increased . Nesting score, however, was only improved in antibiotics-treated mice. These animals additionally displayed reduced plaque load in the hippocampus. While various physiological parameters were not affected, blood sugar was reduced and serum glucagon level significantly elevated in the antibiotics-treated animals together with a reduction in the receptor for advanced glycation end products RAGE-the inward transporter of Aβ peptides of the brain. Assumedly, the beneficial effect of the antibiotics was based on their anti-diabetic potential.
肠道-脑轴似乎调节着各种精神和神经疾病，如阿尔茨海默病（AD）。越来越多的证据表明，肠道微生物群可能促成这些疾病，甚至是这些疾病的起源核心。在这方面，微生物组成的调节剂可能提供有吸引力的新疗法。我们研究的目的是阐明严格改变的肠道微生物群对AD病理特征的影响。5xFAD模型小鼠用抗生素或益生菌（和）治疗14周。通过筑巢能力和斑块沉积来测量发病机制。肠道微生物群如预期受到影响：抗生素显著减少了活的共生菌，而益生菌则短暂增加了。然而，筑巢评分仅在抗生素治疗的小鼠中得到改善。这些动物在海马体中的斑块负荷也有所降低。虽然各种生理参数未受影响，但抗生素治疗的动物血糖降低，血清胰高血糖素水平显著升高，同时晚期糖基化终产物受体RAGE（大脑中Aβ肽的内向转运体）减少。据推测，抗生素的有益作用基于其抗糖尿病潜力。
