活性羰基化合物与蛋白质加合物：鉴定策略、生物学机制及其解毒的分子方法
Reactive Carbonyl Species and Protein Adducts: Identification Strategies, Biological Mechanisms and Molecular Approaches for Their Detoxification.
作者信息
Aldini Giancarlo, Altomare Alessandra A
机构信息
Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy.
出版信息
Antioxidants (Basel). 2021 Apr 28;10(5):690. doi: 10.3390/antiox10050690.
Abstract
The Special issue is composed of 13 contributions: 9 research papers and 4 reviews [...].
摘要
该特刊由13篇稿件组成：9篇研究论文和4篇综述 [...]。
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Reactive Carbonyl Species and Protein Adducts: Identification Strategies, Biological Mechanisms and Molecular Approaches for Their Detoxification.活性羰基化合物与蛋白质加合物：鉴定策略、生物学机制及其解毒的分子方法
Antioxidants (Basel). 2021 Apr 28;10(5):690. doi: 10.3390/antiox10050690.
2
Mass spectrometric approaches for the identification and quantification of reactive carbonyl species protein adducts.基于质谱的方法鉴定和定量活性羰基物种蛋白质加合物。
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Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?脂质氧化产物与肽和蛋白质的结合：有害修饰还是信号机制？
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Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras mice.糖尿病通过增加 Kras 小鼠全身和肿瘤羰基应激促进侵袭性胰腺癌。
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本文引用的文献
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A Workflow towards the Reproducible Identification and Quantitation of Protein Carbonylation Sites in Human Plasma.一种用于在人血浆中可重复鉴定和定量蛋白质羰基化位点的工作流程。
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Allysine and α-Aminoadipic Acid as Markers of the Glyco-Oxidative Damage to Human Serum Albumin under Pathological Glucose Concentrations.在病理血糖浓度下，醛赖氨酸和α-氨基己二酸作为人血清白蛋白糖氧化损伤的标志物。
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In-Depth AGE and ALE Profiling of Human Albumin in Heart Failure: Ex Vivo Studies.心力衰竭患者人白蛋白的深度AGE和ALE分析：体外研究
Antioxidants (Basel). 2021 Feb 27;10(3):358. doi: 10.3390/antiox10030358.
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4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation.4-羟基壬烯醛在紫外线A辐射引起的皮肤光老化中促成成纤维细胞衰老。
Antioxidants (Basel). 2021 Feb 28;10(3):365. doi: 10.3390/antiox10030365.
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Protein Lipoxidation: Basic Concepts and Emerging Roles.蛋白质脂氧化：基本概念与新出现的作用
Antioxidants (Basel). 2021 Feb 16;10(2):295. doi: 10.3390/antiox10020295.
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Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation.血红素铁诱导肠腔内4-羟基壬烯醛的产生可能通过蛋白质加合物的形成产生肠外后果。
Antioxidants (Basel). 2020 Dec 17;9(12):1293. doi: 10.3390/antiox9121293.
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Protein Carbonylation and Lipid Peroxidation in Hematological Malignancies.血液系统恶性肿瘤中的蛋白质羰基化和脂质过氧化
Antioxidants (Basel). 2020 Dec 1;9(12):1212. doi: 10.3390/antiox9121212.
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Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging.组蛋白羰基化是一种受氧化还原调节的表观基因组标记，其会随着肥胖和衰老而积累。
Antioxidants (Basel). 2020 Dec 1;9(12):1210. doi: 10.3390/antiox9121210.
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Downregulation of the Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats.该基因的下调与自发性高血压大鼠的肥胖减轻和异位脂肪堆积减少有关。
Antioxidants (Basel). 2020 Nov 26;9(12):1179. doi: 10.3390/antiox9121179.
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Profiling of Low-Molecular-Weight Carbonyls and Protein Modifications in Flavored Milk.调味乳中低分子量羰基化合物和蛋白质修饰的分析
Antioxidants (Basel). 2020 Nov 23;9(11):1169. doi: 10.3390/antiox9111169.
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