Jabalera Ylenia, Sola-Leyva Alberto, Carrasco-Jiménez María P, Iglesias Guillermo R, Jimenez-Lopez Concepcion
Department of Microbiology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
Department of Biochemistry and Molecular Biology I, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
Pharmaceutics. 2021 Apr 28;13(5):625. doi: 10.3390/pharmaceutics13050625.
MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of the most promising nanomaterials due to their magnetic features (superparamagnetic character and large magnetic moment per particle), their novel surface properties determined by MamC, their biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach an effective temperature at the target site, relatively high nanoparticle concentration, as well as high magnetic field strength and/or AC frequency are needed. In the present study, the potential of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at a wavelength at which tissues become partially transparent, is explored. Moreover, our results also demonstrate the synergy between photothermia and chemotherapy in terms of drug release and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the present study open the possibility of a novel, alternative approach to fight localized tumors.
MamC介导的仿生磁性纳米颗粒（BMNPs）因其磁性特征（超顺磁性和每个颗粒的大磁矩）、由MamC决定的新型表面性质、生物相容性以及作为磁热疗剂的能力，已成为最有前途的纳米材料之一。然而，磁热疗目前的临床应用受到限制，因为为了能够在靶部位达到有效温度，需要相对较高的纳米颗粒浓度以及高磁场强度和/或交流频率。在本研究中，探索了BMNPs在近红外激光束照射下升温的潜力，该波长下组织会部分透明。此外，我们的结果还通过使用用阿霉素功能化的BMNPs，证明了光热疗和化疗在药物释放和细胞毒性方面的协同作用，以及这种联合疗法在体外实验中对肿瘤细胞的有效性。因此，本研究的结果为对抗局部肿瘤开辟了一种新颖的替代方法的可能性。
