Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Int J Mol Sci. 2021 Apr 26;22(9):4523. doi: 10.3390/ijms22094523.
Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNA during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effects, therapeutic targets, and mechanisms of action of WRS are still at an emerging stage. This review summarizes the involvement of WRS in human diseases. We hope that this will encourage further investigation into WRS as a potential target for drug development in various pathological states including infection, tumorigenesis, and autoimmune and brain diseases.
色氨酰-tRNA 合成酶（WRS）是一种必需的酶，在翻译过程中通过氨酰化催化色氨酸（Trp）与其对应的 tRNA 的连接。有趣的是，WRS 在包括败血症、癌症、自身免疫和脑部疾病在内的疾病中也具有生理病理学作用，并具有作为药理学靶点和治疗剂的潜力。然而，WRS 通常仍被简单地视为在多肽中产生 Trp 的酶；因此，WRS 的药理学作用、治疗靶点和作用机制的研究仍处于新兴阶段。本综述总结了 WRS 与人类疾病的关系。我们希望这将鼓励进一步研究 WRS 作为包括感染、肿瘤发生、自身免疫和脑部疾病在内的各种病理状态下药物开发的潜在靶点。
