Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Association of Dutch Burn Centres, Maasstad Hospital, Rotterdam, The Netherlands.
Health Qual Life Outcomes. 2021 Apr 29;19(1):135. doi: 10.1186/s12955-021-01771-3.
Fatigue negatively influences health-related quality of life. It is questionable whether fatigue is sufficiently covered by the EQ-5D. This study investigated whether fatigue is covered by the existing domains of the EQ-5D.
A Dutch general population sample completed the EQ-5D (3L and 5L version) and the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), of which the fatigue item was used. Outcomes were compared between participants with and without a chronic health condition. Convergent validity was assessed, and multivariate regression analyses was used to predict the RPQ fatigue item from the EQ-5D-3L and EQ-5D-5L domains separately.
3027 people completed the survey, of whom 52% had ≥ 1 chronic health condition. Fatigue was reported by 48% of the participants. Fatigue was moderately correlated to the EQ-5D domains 'pain/discomfort', 'usual activities', and 'anxiety/depression' for the 3L (r = 0.379-0.426) and 5L version (r = 0.411-0.469). For the 5L, also a moderate correlation with 'mobility' (r = 0.335) was observed. The remaining correlations were weak. All EQ-5D-3L and 5L domains except for 'mobility' were significantly associated with the RPQ fatigue item (unstandardized Beta = - 0.20-0.67; p < 0.01 to p = 0.04). Comparable outcomes were found for participants with and without ≥ 1 chronic health condition.
The extent to which fatigue is covered by the EQ-5D domains is small to moderate, with the EQ-5D-5L being slightly more sensitive to capture fatigue compared to the EQ-5D-3L. An extra fatigue item for the EQ-5D may add value, as fatigue is not fully captured by the existing domains, both in people with and without a chronic health condition.
疲劳会对健康相关的生活质量产生负面影响。目前尚不清楚 EQ-5D 是否充分涵盖了疲劳问题。本研究旨在调查疲劳是否被 EQ-5D 的现有维度所涵盖。
采用荷兰一般人群样本完成 EQ-5D（3L 和 5L 版本）和 Rivermead 脑震荡后症状问卷（RPQ），其中使用了疲劳项目。将有和无慢性健康状况的参与者的结果进行比较。评估了收敛有效性，并使用多元回归分析分别从 EQ-5D-3L 和 EQ-5D-5L 维度预测 RPQ 疲劳项目。
共有 3027 人完成了调查，其中 52%有≥1 种慢性健康状况。48%的参与者报告存在疲劳。对于 3L 版本（r=0.379-0.426）和 5L 版本（r=0.411-0.469），疲劳与 EQ-5D 维度“疼痛/不适”、“日常活动”和“焦虑/抑郁”中度相关。对于 5L 版本，也观察到与“行动能力”中度相关（r=0.335）。其余相关性较弱。除“行动能力”外，所有 EQ-5D-3L 和 5L 维度均与 RPQ 疲劳项目显著相关（未标准化 Beta=-0.20-0.67；p<0.01 至 p=0.04）。在有≥1 种慢性健康状况和无慢性健康状况的参与者中均发现了类似的结果。
疲劳在 EQ-5D 维度中的涵盖程度较小到中等，EQ-5D-5L 比 EQ-5D-3L 更能敏感地捕捉疲劳。在现有的维度中，EQ-5D 增加一个疲劳项目可能会增加价值，因为无论是在有慢性健康状况的人群还是没有慢性健康状况的人群中，现有的维度都不能完全捕捉到疲劳。
