Hisaki T, Furumoto T, Nozaka K, Kono K, Odachi T, Mizumoto K, Nishimura O, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Jpn J Surg. 1988 Mar;18(2):158-63. doi: 10.1007/BF02471425.
Serum zinc and copper levels were evaluated in patients with gastric cancer who had undergone gastrectomy. These patients were divided into two age categories; namely, the aged group, comprising 39 patients over the age of 70 years, and the younger group, comprising 23 patients younger than 50 years. The data before and after surgery were compared between the two groups. Serum zinc levels in the aged group were significantly lower than those in the younger group, both before and after surgery. Serum copper levels, however, did not differ significantly between the two groups. The serum Cu/Zn ratio was also analyzed according to the histological stages of cancer (stages I to IV), and compared between the two age-classified groups. The aged group showed a higher Cu/Zn ratio at all stages, whereas in the younger group, the ratio was significantly higher at stage IV than in the earlier stages. Preoperative serum zinc, copper, and the Cu/Zn ratio were studied in relation to the complication of anastomotic leak after surgery. The Cu/Zn ratio in the aged patients with this complication was significantly higher than that in the aged patients without it. These results suggest that the Cu/Zn ratio may be an important factor in determining nutritional parameters in the aged.
对接受胃切除术的胃癌患者的血清锌和铜水平进行了评估。这些患者被分为两个年龄组；即老年组，包括39名70岁以上的患者，以及年轻组，包括23名50岁以下的患者。比较了两组手术前后的数据。老年组的血清锌水平在手术前后均显著低于年轻组。然而，两组之间的血清铜水平没有显著差异。还根据癌症的组织学阶段（I至IV期）分析了血清铜/锌比值，并在两个年龄分类组之间进行了比较。老年组在所有阶段的铜/锌比值都较高，而在年轻组中，IV期的比值明显高于早期。研究了术前血清锌、铜和铜/锌比值与术后吻合口漏并发症的关系。有这种并发症的老年患者的铜/锌比值明显高于没有这种并发症的老年患者。这些结果表明，铜/锌比值可能是决定老年人营养参数的一个重要因素。
