Wu C W, Wei Y Y, Chi C W, Lui W Y, P'Eng F K, Chung C
Department of Surgery, Veterans General Hospital, Taipei, Taiwan.
Dig Dis Sci. 1996 Jan;41(1):119-25. doi: 10.1007/BF02208592.
The contents of 10 minor and trace elements in histologically confirmed gastric adenocarcinomas and their corresponding normal gastric mucosal tissues obtained from 39 patients at the time of gastric resection were simultaneously determined by instrumental neutron activation analysis. Specimens were irradiated by reactor neutrons and subsequently subject to direct analysis using a high-resolution HPGe gamma-spectrometer. Univariate analysis revealed that gastric cancer tissues had significantly higher concentrations of Fe, K, Mg, Na, Rb, Se, and Zn than normal gastric mucosal tissues. However, multivariate analysis found that Fe, K, and Se were independent elements that associated with gastric cancer. Upon further evaluation of their clinical significance, we found a high tissue K level was related to lymphatic duct metastasis. High Se tissue levels were linked to intestinal type adenocarcinoma. A positive correlation was found between high Fe levels and vascular involvement. These findings suggest that Fe and K are associated with gastric cancer progression. Se is involved in carcinogenesis of stomach in high-risk areas. The mechanisms that underlie the corresponding pathohistological features deserve further study.
采用仪器中子活化分析法，同时测定了39例胃癌患者胃切除时获得的组织学确诊的胃腺癌及其相应正常胃黏膜组织中10种微量和痕量元素的含量。标本用反应堆中子辐照，随后使用高分辨率HPGeγ谱仪进行直接分析。单因素分析显示，胃癌组织中Fe、K、Mg、Na、Rb、Se和Zn的浓度显著高于正常胃黏膜组织。然而，多因素分析发现，Fe、K和Se是与胃癌相关的独立元素。在进一步评估它们的临床意义时，我们发现组织K水平高与淋巴管转移有关。组织Se水平高与肠型腺癌有关。Fe水平高与血管侵犯之间存在正相关。这些发现表明，Fe和K与胃癌进展有关。Se参与高危地区胃癌的致癌过程。相应病理组织学特征的潜在机制值得进一步研究。
