State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100008, China.
Oxid Med Cell Longev. 2021 Apr 10;2021:5518825. doi: 10.1155/2021/5518825. eCollection 2021.
Due to the challenges of antibiotic resistance to global health, bacteriocins as antimicrobial compounds have received more and more attention. Bacteriocins are biosynthesized by various microbes and are predominantly used as food preservatives to control foodborne pathogens. Now, increasing researches have focused on bacteriocins as potential clinical antimicrobials or immune-modulating agents to fight against the global threat to human health. Given the broad- or narrow-spectrum antimicrobial activity, bacteriocins have been reported to inhibit a wide range of clinically pathogenic and multidrug-resistant bacteria, thus preventing the infections caused by these bacteria in the human body. Otherwise, some bacteriocins also show anticancer, anti-inflammatory, and immune-modulatory activities. Because of the safety and being not easy to cause drug resistance, some bacteriocins appear to have better efficacy and application prospects than existing therapeutic agents do. In this review, we highlight the potential therapeutic activities of bacteriocins and suggest opportunities for their application.
由于抗生素耐药性对全球健康构成的挑战，细菌素作为抗菌化合物受到了越来越多的关注。细菌素由各种微生物生物合成，主要用作食品防腐剂，以控制食源性病原体。现在，越来越多的研究集中在细菌素作为潜在的临床抗菌药物或免疫调节剂上，以对抗对人类健康的全球威胁。鉴于其广谱或窄谱抗菌活性，细菌素已被报道能抑制广泛的临床致病性和多药耐药菌，从而防止这些细菌在人体内引起感染。此外，一些细菌素还具有抗癌、抗炎和免疫调节活性。由于安全性和不易产生耐药性，一些细菌素的疗效和应用前景似乎优于现有治疗药物。在这篇综述中，我们强调了细菌素的潜在治疗活性，并提出了它们应用的机会。
