Song Ke, Wang Yong, Ren Mei-Xia, Li Jiao, Su Ting, Chen Si-Yi, Shao Yi, Lv Ya-Li
Department of Equipment, Xi'an People's Hospital, Xi'an Fourth Hospital, Xi'an, China.
Department of Ophthalmology, Xi'an People's Hospital, Xi'an Fourth Hospital, Xi'an, China.
Front Neurosci. 2021 Oct 14;15:718973. doi: 10.3389/fnins.2021.718973. eCollection 2021.
Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON). We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs. The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs. Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.
我们利用静息态功能连接（rsFC），研究了视神经炎（ON）患者中由功能连接密度（FCD）反映的自发脑活动变化。我们招募了28例ON患者（18例男性，10例女性）和24名健康对照者（HCs；16例男性，8例女性）。所有受试者在安静状态下接受功能磁共振成像（fMRI），以确定rsFC、长程FCD（longFCD）和短程FCD（IFCD）的值。生成受试者工作特征（ROC）曲线以区分患者和HCs。ON组在左侧额下回三角区、右侧楔前叶、右侧前扣带回以及扣带旁回/中央扣带回和扣带旁回中表现出明显较低的longFCD值。左侧中央扣带回和扣带旁回以及辅助运动区（SMA）也显著降低。与HCs相比，在左侧颞中回/角回/SMA和右侧楔叶/SMA中观察到IFCD值明显降低。在ON患者的特定脑区发现了异常神经活动。具体而言，他们在rsFC、longFCD和IFCD值上表现出显著变化。这些可能有助于确定ON脑功能变化的具体机制。
