Division of Ophthalmology and Optometry, Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Toruń, Poland.
Ophthalmic Physiol Opt. 2021 Jul;41(4):683-690. doi: 10.1111/opo.12830. Epub 2021 May 4.
To measure geometrical changes in the anterior surface of the cornea after wearing silicon hydrogel (SiH) soft contact lenses continuously for 1 week.
Forty-three eyes with 3.0D of myopia and 22 eyes with 3.0D of hyperopia were enrolled in the prospective, interventional study. All subjects underwent a general eye examination, corneal tomography with wavefront aberration analysis, corneal thickness measurements and epithelial thickness mapping before and after wearing SiH lenses (Acuvue Oasys) for 7 days.
No significant changes in average keratometry were observed in either refractive group. In the myopic group, keratometry findings for the flat meridian (K1) and central corneal thickness decreased significantly. After +3.0 D lens wear in the hyperopic group, a significant decrease in epithelial thickness up to 3.19 µm was observed in the central and paracentral cornea, (p < 0.001). In both refractive groups, the largest epithelial thickness increase was seen in the periphery. A decrease in spherical aberration was noted in myopic eyes, while an increase of both higher order corneal aberrations and coma was found in hyperopic subjects.
Extended wear of SiH lenses results in a significant change in epithelial thickness leading to alteration in the geometry of the anterior surface of the cornea, particularly in hyperopic patients. These epithelial thickness variations lead to changes in the higher order aberrations of the cornea.
测量硅水凝胶（SiH）软性隐形眼镜连续佩戴 1 周后角膜前表面的几何变化。
前瞻性、干预性研究纳入 43 只近视 3.0D 眼和 22 只远视 3.0D 眼。所有受试者在佩戴 SiH 镜片（Acuvue Oasys）前后均进行了一般眼部检查、角膜断层扫描伴波前像差分析、角膜厚度测量和上皮厚度测绘。
在两个屈光组中，平均角膜曲率均无显著变化。在近视组中，扁平子午线（K1）和中央角膜厚度的角膜曲率测量结果显著降低。在远视组中，+3.0 D 镜片佩戴后，中央和旁中央角膜的上皮厚度显著减少 3.19 µm（p < 0.001）。在两个屈光组中，最大的上皮厚度增加均见于周边部。近视眼中球差减少，远视眼则发现高阶角膜像差和彗差增加。
硅水凝胶隐形眼镜的长期佩戴会导致上皮厚度发生显著变化，从而改变角膜前表面的几何形状，特别是在远视患者中。这些上皮厚度的变化会导致角膜高阶像差的改变。
