Vilibic-Cavlek Tatjana, Oreski Tena, Korva Misa, Kolaric Branko, Stevanovic Vladimir, Zidovec-Lepej Snjezana, Tabain Irena, Jelicic Pavle, Miklausic-Pavic Bozana, Savic Vladimir, Barbic Ljubo, Avsic-Zupanc Tatjana
Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia.
Department of Microbiology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Trop Med Infect Dis. 2021 Apr 29;6(2):67. doi: 10.3390/tropicalmed6020067.
Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019-8.607).
淋巴细胞性脉络丛脑膜炎病毒（LCMV）是一种被忽视的人类病原体，与无菌性脑膜炎、免疫功能低下者的严重全身感染以及先天性异常有关。关于LCMV感染患病率的数据很少。我们分析了克罗地亚大陆地区LCMV的血清阳性率。使用间接免疫荧光法对338份专业暴露人群（林业工人、猎人、接触啮齿动物的农业工人）和非暴露人群（普通人群、孕妇）的血清样本进行了LCMV抗体检测。没有参与者报告近期有发热疾病。在23名（6.8%）参与者中检测到LCMV IgG抗体：9.8%的暴露者和5.1%的非暴露者（普通人群中为6.1%，孕妇中为3.9%）。没有参与者LCMV IgM呈阳性。虽然男性的血清阳性率高于女性（8.9%对4.7%），郊区/农村居民高于城市居民（9.2%对4.6%），使用井水作为水源的人高于使用自来水的人（11.4%对5.6%），但这些差异没有达到统计学意义。逻辑回归结果显示，房屋/院子里有啮齿动物以及清理啮齿动物巢穴与LCMV感染风险升高有关（OR = 2.962，95% CI = 1.019 - 8.607）。
