Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
Department of Botany and Genetics, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.
Molecules. 2021 Apr 29;26(9):2616. doi: 10.3390/molecules26092616.
This study examined for the first time whether bee bread (BB, consisting of monofloral rape bee pollen) could alleviate lipid derangements and reduced bone quality in Zucker diabetic fatty (ZDF) rats, which are considered an appropriate animal model for type 2 diabetes mellitus (T2DM) investigation. Adult ZDF rats were segregated into four groups: lean non-diabetic rats (L group), obese diabetic rats untreated (C group), and those treated with the BB at two doses (500 and 700 mg/kg body weight, respectively, B1 and B2 groups) for 10 weeks. Significantly reduced levels of total cholesterol and triglyceride were recorded in the B2 group versus the C group. In both BB-treated groups, significantly increased relative volume of trabecular bone and trabecular thickness, enhanced density of secondary osteons, accelerated periosteal bone apposition, and improved blood flow were observed. A positive effect of higher dose of BB on femoral weight and cortical bone thickness was also demonstrated. Our results suggest a promising potential of BB to ameliorate T2DM-related complications associated with lipid and bone damages.
本研究首次考察了蜂粮（BB，由单花油菜蜂花粉组成）是否可以缓解脂肪代谢紊乱并改善 Zucker 肥胖型糖尿病（ZDF）大鼠的骨质量，该大鼠被认为是研究 2 型糖尿病（T2DM）的合适动物模型。将成年 ZDF 大鼠分为四组：瘦非糖尿病大鼠（L 组）、肥胖未治疗糖尿病大鼠（C 组）和分别用两种剂量（500 和 700mg/kg 体重，B1 和 B2 组）的 BB 治疗 10 周的大鼠。与 C 组相比，B2 组的总胆固醇和甘油三酯水平显著降低。在 BB 治疗组中，均观察到小梁骨相对体积增加，小梁厚度增加，次生骨单位密度增加，骨膜骨形成加速，血流改善。还证明了 BB 较高剂量对股骨重量和皮质骨厚度的积极影响。我们的结果表明，BB 具有改善与脂质和骨损伤相关的 T2DM 相关并发症的潜力。
