长链非编码 RNA PVT1 在肾细胞癌发病机制和临床管理中的作用。
lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma.
机构信息
Central European Institute of Technology, Masaryk University, 625 00 Brno, Czech Republic.
Department of Pharmacology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.
出版信息
Biomolecules. 2021 Apr 29;11(5):664. doi: 10.3390/biom11050664.
LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. In this review, we summarize the literature focused on PVT1 in RCC and aim to synthesize the current knowledge on its role in the cells of the kidney. Further, we provide an overview of the lncRNA profiling studies that have identified a more or less significant association of PVT1 with the clinical behavior of RCC. Based on our search, we analyzed the 17 scientific papers discussed in this review that provide robust support for the indispensable role of PVT1 in RCC development and future personalized therapy.
长链非编码 RNA PVT1（浆细胞瘤变异易位 1）已成为肾细胞癌（RCC）患者 lncRNA 图谱的主要内容。在肾肿瘤中常见的失调表明 PVT1 在 RCC 发展中的重要作用。已经有大量的出版物试图揭示 PVT1 介导的调节的细胞机制及其在 RCC 管理中的潜在利用。在这篇综述中，我们总结了 PVT1 在 RCC 中的文献，并旨在综合目前关于其在肾脏细胞中的作用的知识。此外，我们还概述了 lncRNA 分析研究，这些研究或多或少地确定了 PVT1 与 RCC 临床行为的显著相关性。根据我们的搜索，我们分析了这篇综述中讨论的 17 篇科学论文，这些论文为 PVT1 在 RCC 发展和未来个性化治疗中的不可或缺作用提供了有力的支持。
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