Roberts A B, Baker J R, James A G, Henley P
Department of Obstetrics, Gynecology, and Neonatology, National Womens Hospital, Auckland, New Zealand.
Am J Obstet Gynecol. 1988 Jul;159(1):66-71. doi: 10.1016/0002-9378(88)90495-4.
The role of maternal serum fructosamine estimation in the management of gestational diabetes was assessed in 78 consecutive patients over a 3-year period. Fructosamine results correlated significantly with mean plasma glucose levels over a 1- to 3-week interval, with the closest association being in the preceding week. Eighty-five percent of women with gestational diabetes had peak serum fructosamine levels above the normal range. If maternal levels exceeded 3.2 mmol/L, there was an 88% chance of abnormal glucose tolerance post partum. Our aim of management was a serum fructosamine level less than 2.5 mmol/L; patients who achieved this goal by 35 to 37 weeks' gestation had fewer obese babies with lower cord insulin and C-peptide levels as compared with neonates of mothers with elevated fructosamine concentrations.
在3年时间里对78例连续妊娠的患者评估了母体血清果糖胺测定在妊娠期糖尿病管理中的作用。果糖胺结果与1至3周期间的平均血糖水平显著相关，最密切的关联出现在前一周。85%的妊娠期糖尿病女性血清果糖胺峰值水平高于正常范围。如果母体水平超过3.2 mmol/L，产后葡萄糖耐量异常的几率为88%。我们的管理目标是血清果糖胺水平低于2.5 mmol/L；与果糖胺浓度升高的母亲所生新生儿相比，在妊娠35至37周时达到这一目标的患者所生肥胖婴儿较少，脐带胰岛素和C肽水平较低。
