生物活性玻璃激活心肌细胞的血管内皮生长因子旁分泌信号传导，以促进心脏血管生成。
Bioactive glass activates VEGF paracrine signaling of cardiomyocytes to promote cardiac angiogenesis.
作者信息
Shi Miao, Zhao Fujian, Sun Luyao, Tang Fengling, Gao Wendong, Xie Weihan, Cao Xiaodong, Zhuang Jian, Chen Xiaofeng
机构信息
School of Medicine, South China University of Technology, Guangzhou 510006, PR China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, PR China; Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, PR China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2021 May;124:112077. doi: 10.1016/j.msec.2021.112077. Epub 2021 Mar 26.
The heart contains a wide range of cell types, which are not isolated but interact with one another via multifarious paracrine, autocrine and endocrine factors. In terms of cardiac angiogenesis, previous studies have proved that regulating the communication between cardiomyocytes and endothelial cells is efficacious to promote capillary formation. Firstly, this study investigated the effect and underlying mechanism of bioactive glass (BG) acted on vascular endothelial growth factor (VEGF) paracrine signaling in cardiomyocytes. We found that bioactive ions released from BG significantly promoted the VEGF production and secretion of cardiomyocytes. Subsequently, we proved that cardiomyocyte-derived VEGF played an important role in mediating the behavior of endothelial cells. Further research showed that the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway was upregulated by BG, which was involved in VEGF expression of cardiomyocytes. This study revealed that by means of modulating cellular crosstalk via paracrine signaling of host cells in heart is a new direction for the application of BGs in cardiac angiogenesis.
心脏包含多种细胞类型，这些细胞并非孤立存在，而是通过多种旁分泌、自分泌和内分泌因子相互作用。就心脏血管生成而言，先前的研究已证明，调节心肌细胞与内皮细胞之间的通讯对于促进毛细血管形成是有效的。首先，本研究调查了生物活性玻璃（BG）作用于心肌细胞中血管内皮生长因子（VEGF）旁分泌信号的效果及潜在机制。我们发现，BG释放的生物活性离子显著促进了心肌细胞中VEGF的产生和分泌。随后，我们证明了心肌细胞衍生的VEGF在介导内皮细胞行为中发挥着重要作用。进一步的研究表明，BG上调了磷酸肌醇3激酶（PI3K）/蛋白激酶B（Akt）/缺氧诱导因子1α（HIF-1α）信号通路，该通路参与心肌细胞中VEGF的表达。本研究表明，通过调节心脏中宿主细胞的旁分泌信号来调节细胞间相互作用，是BG在心脏血管生成中应用的一个新方向。
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