老年营养风险指数与中国老年人群新发高血压的关联：一项为期6年的队列研究。
Association of the Geriatric Nutritional Risk Index with incident hypertension in the older Chinese population: a 6-year cohort study.
作者信息
Su Zhongjian, Zhang Xing, Zheng Nan, Xiao Ying, Liu Xingzhu, Yang Yanfei, Deng Lili, Chen Yanfei, Li Bin
机构信息
Department of Cardiovascular Medicine, Kunming Children's Hospital, Kunming, Yunnan Province, China.
出版信息
J Int Med Res. 2021 May;49(5):3000605211010051. doi: 10.1177/03000605211010051.
BACKGROUND
We examined the association of the Geriatric Nutritional Risk Index (GNRI) with the incidence of hypertension.
METHODS
We used data of the China Health and Nutrition Survey in this study. Participants aged ≥60 years were eligible. The GNRI was defined as follows: GNRI = [1.489 × albumin (ALB; g/L)] + [41.7 × (actual weight/ideal weight)]. Participants with systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive medication were defined as having hypertension.
RESULTS
This study included 4853 participants, comprising 3612 control participants and 1241 participants with hypertension. The GNRI, ALB, and body mass index (BMI) were significantly associated with higher incidence of hypertension (HR: 1.030, 1.026, and 1.088; 95% CI: 1.020-1.041, 1.008-1.044, and 1.069-1.107, respectively). The GNRI, ALB, and BMI were associated with an earlier age of hypertension onset (β = -0.403, -0.613, and -0.321; 95% CI: -0.493 to -0.314, -0.767 to -0.459, and -0.484 to -0.159, respectively).
CONCLUSIONS
A higher GNRI was associated with increased incidence of hypertension. An elevated GNRI was associated with earlier age of hypertension onset.
背景
我们研究了老年营养风险指数（GNRI）与高血压发病率之间的关联。
方法
本研究使用了中国健康与营养调查的数据。年龄≥60岁的参与者符合条件。GNRI的定义如下：GNRI = [1.489×白蛋白（ALB；g/L）]+[41.7×（实际体重/理想体重）]。收缩压≥140 mmHg、舒张压≥90 mmHg或使用抗高血压药物的参与者被定义为患有高血压。
结果
本研究纳入了4853名参与者，其中包括3612名对照参与者和1241名高血压患者。GNRI、ALB和体重指数（BMI）与高血压发病率较高显著相关（HR分别为：1.030、1.026和1.088；95%CI分别为：1.020 - 1.041、1.008 - 1.044和1.069 - 1.107）。GNRI、ALB和BMI与高血压发病年龄较早相关（β分别为：-0.403、-0.613和-0.321；95%CI分别为：-0.493至-0.314、-0.767至-0.459和-0.484至-0.159）。
结论
较高的GNRI与高血压发病率增加相关。GNRI升高与高血压发病年龄较早相关。
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