Center for Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington, USA.
Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
J Adolesc Young Adult Oncol. 2021 Dec;10(6):703-710. doi: 10.1089/jayao.2020.0223. Epub 2021 May 6.
A diagnosis of cancer often derails an individual's goals. The purpose of this mixed-methods analysis was to describe the evolution of adolescent and young adult (AYA)-reported goals in the year after a diagnosis of new or advanced cancer. As part of the Promoting Resilience in Stress Management (PRISM) phase 2 randomized controlled trial, AYAs with cancer (ages 12-25 years) were asked at baseline, 6 months, and 12 months: "Please give an example of a goal you hope to accomplish over the next month/year." We used content analysis to categorize goals as follows: life milestones, physical health, mental/emotional health, cancer specific, and hobbies/interests. We summarized goal categories at each time point: for the entire cohort, by baseline diagnosis status (new vs. advanced cancer), treatment status (on-therapy vs. off-therapy), and baseline health-related quality of life (high vs. low). Eighty-six participants completed the study and were included in the analysis (control: = 41, PRISM: = 45); 69 reported their goals at 6 months, and 54 at 12 months. Participants submitted a total of 169 goals at baseline, 148 at 6 months, and 126 at 12 months. At baseline, cancer-specific goals were most common for the short-term (35%), whereas milestone goals were most common for the long-term (46%). At 6 months, milestone goals were most common in both short- (38%) and long-term (51%) categories. A similar pattern was seen at 12 months. AYAs' goals change over the first year of their cancer experience, with a shift in short-term goals from cancer-specific goals at baseline to milestone goals at later time points. ClinicalTrials.gov (NCT02340884).
癌症诊断通常会打乱个人的目标。本混合方法分析的目的是描述青少年和年轻成人（AYA）在新诊断或晚期癌症后一年内报告的目标的演变。作为促进应激管理中的韧性（PRISM）阶段 2 随机对照试验的一部分，患有癌症的 AYA（12-25 岁）在基线、6 个月和 12 个月时被问到：“请举例说明您希望在下一个月/年内完成的目标。”我们使用内容分析将目标分为以下几类：生活里程碑、身体健康、心理健康、癌症特异性和爱好/兴趣。我们在每个时间点总结目标类别：整个队列、按基线诊断状态（新诊断与晚期癌症）、治疗状态（治疗中与治疗结束）和基线健康相关生活质量（高与低）。86 名参与者完成了研究并被纳入分析（对照组：=41，PRISM 组：=45）；69 名报告了他们在 6 个月时的目标，54 名报告了他们在 12 个月时的目标。参与者共提交了 169 个基线目标，148 个 6 个月目标，126 个 12 个月目标。在基线时，短期内癌症特异性目标最常见（35%），而里程碑目标在长期内最常见（46%）。在 6 个月时，两种短期（38%）和长期（51%）目标都最常见。12 个月时也出现了类似的模式。在癌症经历的第一年，AYA 的目标发生了变化，短期内的目标从基线时的癌症特异性目标转变为后期的里程碑目标。ClinicalTrials.gov（NCT02340884）。
