Shi Chen, Andino-Pavlovsky Victoria, Lee Stephen A, Costa Tiago, Elloian Jeffrey, Konofagou Elisa E, Shepard Kenneth L
Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Sci Adv. 2021 May 7;7(19). doi: 10.1126/sciadv.abf6312. Print 2021 May.
There has been increasing interest in wireless, miniaturized implantable medical devices for in vivo and in situ physiological monitoring. Here, we present such an implant that uses a conventional ultrasound imager for wireless powering and data communication and acts as a probe for real-time temperature sensing, including the monitoring of body temperature and temperature changes resulting from therapeutic application of ultrasound. The sub-0.1-mm, sub-1-nW device, referred to as a mote, achieves aggressive miniaturization through the monolithic integration of a custom low-power temperature sensor chip with a microscale piezoelectric transducer fabricated on top of the chip. The small displaced volume of these motes allows them to be implanted or injected using minimally invasive techniques with improved biocompatibility. We demonstrate their sensing functionality in vivo for an ultrasound neurostimulation procedure in mice. Our motes have the potential to be adapted to the distributed and localized sensing of other clinically relevant physiological parameters.
对于用于体内和原位生理监测的无线、小型化可植入医疗设备的兴趣与日俱增。在此，我们展示了一种植入物，它利用传统超声成像仪进行无线供电和数据通信，并作为实时温度传感的探头，包括监测体温以及超声治疗应用引起的温度变化。这种尺寸小于0.1毫米、功耗低于1纳瓦的设备，称为微尘，通过将定制的低功耗温度传感器芯片与芯片顶部制造的微尺度压电换能器进行单片集成，实现了高度的小型化。这些微尘的微小位移体积使得它们能够使用具有更好生物相容性的微创技术进行植入或注射。我们在小鼠的超声神经刺激程序中展示了它们在体内的传感功能。我们的微尘有潜力适用于其他临床相关生理参数的分布式和局部传感。
