Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Family Medicine, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan.
Cancer Epidemiol. 2021 Aug;73:101945. doi: 10.1016/j.canep.2021.101945. Epub 2021 May 5.
This study examined the association between cumulative tea consumption over time and various colorectal adenomas as well as their pathology, number, and size.
7355 eligible subjects who underwent health check-ups with colonoscopies were recruited. They were classified into three groups: polyp-free, having low-risk colorectal adenomas, and having high-risk colorectal adenomas. The adenoma pathology, number, and size were collected. We defined 120 mL for each Chinese traditional teapot as a 'cup', and calculated the average daily cups of tea consumed. A 'cup-year' was defined as the daily cups multiplied by the years of tea consumption and was used to express the cumulative amount of tea consumption over time.
Compared to those with no habitual tea consumption, the lowest, middle, and highest tertiles of tea consumption were found to be inversely related to low-risk colorectal adenomas. For high-risk colorectal adenomas, a negative association was found only in the group with the highest tertile of tea consumption. An inverse association between the highest tertile of tea consumption and various features of high-risk colorectal adenomas was also found for villous-rich adenomas and the presence of three or more adenomas, but was not found to be related to adenoma size ≥1 cm.
Tea drinking was inversely associated with both low-risk and high-risk colorectal adenomas. Only a larger cumulative dose of ≥42 cup-years was negatively associated with high-risk colorectal adenomas, especially adenomas with villous-rich pathology and when three or more adenomas were present.
本研究旨在探讨随着时间的推移，累计饮茶量与各种结直肠腺瘤及其病理、数量和大小之间的关系。
共招募了 7355 名符合条件的接受结肠镜健康检查的受试者。他们被分为三组：无息肉组、低危结直肠腺瘤组和高危结直肠腺瘤组。收集腺瘤的病理、数量和大小。我们将每个中国传统茶壶的 120 毫升定义为“一杯”，并计算平均每天饮用的茶杯数。“杯年”定义为每天的杯数乘以饮茶年数，用于表示随着时间的推移累计的饮茶量。
与无习惯性饮茶者相比，饮茶量最低、中、高三分位组与低危结直肠腺瘤呈负相关。对于高危结直肠腺瘤，仅在饮茶量最高三分位组中发现呈负相关。对于绒毛状丰富的腺瘤和存在 3 个或更多腺瘤的高危结直肠腺瘤，饮茶量最高三分位组与各种高危结直肠腺瘤特征呈负相关，但与直径≥1cm 的腺瘤大小无关。
饮茶与低危和高危结直肠腺瘤呈负相关。只有累计剂量≥42 杯年与高危结直肠腺瘤呈负相关，尤其是绒毛状丰富的腺瘤和存在 3 个或更多腺瘤时。
