Production of Mass-Separated Erbium-169 Towards the First Preclinical Investigations.

The β-particle-emitting erbium-169 is a potential radionuclide toward therapy of metastasized cancer diseases. It can be produced in nuclear research reactors, irradiating isotopically-enriched ErO. This path, however, is not suitable for receptor-targeted radionuclide therapy, where high specific molar activities are required. In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating Er from Er targets. The separation efficiency increased up to 0.5% using resonant laser ionization. A subsequent chemical purification process was developed as well as activity standardization of the radionuclidically pure Er. The quality of the Er product permitted radiolabeling and pre-clinical studies. A preliminary experiment was accomplished, using a Er-PSMA-617, to show the potential of Er to reduce tumor cell viability.