维甲酸与变应性鼻炎患者血清白细胞介素-10及转化生长因子-β水平降低相关。
Retinoic Acid Correlates with Reduced Serum IL-10 And TGF-β in Allergic Rhinitis.
作者信息
Davoodi Akram, Lotfi Ramin, Mortazavi Seyed Hamidreza, Gorgin Karaji Ali, Rezaiemanesh Alireza, Salari Farhad
机构信息
Student Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
出版信息
Rep Biochem Mol Biol. 2021 Jan;9(4):399-407. doi: 10.52547/rbmb.9.4.399.
BACKGROUND
Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls.
METHODS
Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls.
RESULTS
IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients.
CONCLUSION
Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
背景
维甲酸（RA）在呼吸道中初始T细胞分化为FOXP3 +调节性T细胞（Treg）的过程中起关键作用。本研究旨在调查变应性鼻炎（AR）患者和健康对照者中RA及Treg相关细胞因子的血清水平、唾液IgA水平、FOXP3和IL-4基因表达，以及RA血清水平与Treg相关细胞因子之间的关系。
方法
采用酶联免疫吸附测定法（ELISA）检测37例AR患者和30例年龄及性别匹配的健康对照者的唾液IgA、血清IgE、RA、IL-10和转化生长因子-β（TGF-β）浓度。
结果
AR患者的IL-10和TGF-β浓度显著低于健康对照者（分别为p < 0.01和P < 0.0001）。患者的唾液IgA显著高于对照者（p < 0.05）。患者与对照者之间的RA无显著差异（p > 0.05）；然而，在AR患者中血清RA与IL-10和TGF-β均呈显著正相关。
结论
我们的数据表明，RA可能通过影响TGF-β和IL-10的产生来影响AR风险。
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