Department of Respiratory and Critical Care Medicine, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China (mainland).
Department of Respiratory and Critical Care Medicine, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China (mainland).
Med Sci Monit. 2021 May 11;27:e929714. doi: 10.12659/MSM.929714.
BACKGROUND The purpose of this study was to assess the effects of seawater on nasal congestion and runny nose symptoms in adults with an acute upper respiratory infection (URI). MATERIAL AND METHODS This was a multicenter retrospective cohort trial of patients with acute URI and symptoms of nasal congestion and runny nose. The patients were assigned to 2 groups and were administered regular non-drug supportive treatment or supportive treatment with nasal irrigation with sea salt-derived physiological saline. The primary efficacy endpoint was the effective rate (percentage of patients with ≥30% symptom score reduction from baseline for nasal congestion and runny nose). RESULTS In total, 144 patients were enrolled, including 72 in each group, and 143 patients completed the study. Both groups had similar demographics and vital signs. The effective rates for nasal congestion and runny nose were significantly increased in the seawater group compared with patients in the control group (87.3% vs 59.7% for nasal congestion; 85.9% vs 61.1% for runny nose; both P<0.001). In addition, the 2 groups showed markedly different degrees of patient symptom score improvement in sleep quality and appetite (both P<0.01), but not in cough and fatigue (both P>0.05). There were no adverse events in either group. CONCLUSIONS The sea salt-derived physiological saline nasal spray device satisfactorily improved nasal congestion, runny nose, sleep quality, and appetite in adults with URI, with no adverse effects.
本研究旨在评估海水对急性上呼吸道感染（URI）成人鼻塞和流涕症状的影响。
这是一项多中心回顾性队列研究，纳入了急性 URI 且伴有鼻塞和流涕症状的患者。将患者分为两组，分别给予常规非药物支持治疗或海水生理盐鼻腔冲洗的支持治疗。主要疗效终点为有效率（鼻塞和流涕症状评分较基线降低≥30%的患者比例）。
共纳入 144 例患者，每组 72 例，143 例患者完成了研究。两组患者的人口统计学特征和生命体征相似。与对照组相比，海水组的鼻塞和流涕有效率显著提高（鼻塞：87.3%比 59.7%；流涕：85.9%比 61.1%；均 P<0.001）。此外，两组患者的睡眠质量和食欲评分均有明显改善（均 P<0.01），但咳嗽和疲劳评分无明显改善（均 P>0.05）。两组均未发生不良事件。
海水生理盐鼻腔喷雾器可显著改善 URI 成人的鼻塞、流涕、睡眠质量和食欲，且无不良反应。
