Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California.
Respir Care. 2021 Jul;66(7):1120-1127. doi: 10.4187/respcare.09052. Epub 2021 May 11.
COPD can lead to abnormalities in oxygenation as well as ventilation. Thanks to pioneering work by Dr Thomas Petty, supplemental oxygen therapy has been shown to improve morbidity and mortality for individuals with COPD and severe daytime hypoxemia. However, efforts to augment ventilation have been less uniformly successful. Recent studies employing a so-called high-intensity noninvasive ventilation strategy, which used high inspiratory pressures and backup breathing frequency to reduce arterial carbon dioxide levels, have shown improved quality of life and reduced mortality. Thus, efforts are underway to better identify and treat patients with COPD who might benefit from noninvasive ventilation, though many practical questions remain.
COPD 可导致氧合和通气异常。多亏了托马斯·佩蒂博士的开创性工作，补充氧疗已被证明可以改善 COPD 和严重日间低氧血症患者的发病率和死亡率。然而，增加通气的努力并没有取得那么一致的成功。最近的研究采用了所谓的高强度无创通气策略，该策略使用高吸气压力和备用呼吸频率来降低动脉二氧化碳水平，已显示出改善生活质量和降低死亡率。因此，正在努力更好地识别和治疗可能受益于无创通气的 COPD 患者，尽管仍存在许多实际问题。
