Division of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Department of Computing, University of Turku, Turku, Finland.
Nat Commun. 2021 May 11;12(1):2671. doi: 10.1038/s41467-021-22962-y.
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.
粪便采集和测序技术的发展使标准化和非侵入性的肠道微生物组分析成为可能。来自多个大型队列的微生物组组成已经与各种生活方式因素和疾病进行了横断面关联。尽管取得了这些进展，但由于缺乏具有全面随访数据的足够大和具有代表性的人群队列，微生物组组成与健康之间的前瞻性关联仍未得到描述。在这里，我们分析了来自芬兰（n=7211）的一个表型良好且具有代表性的人群队列中肠道微生物组变异与死亡率之间的长期关联。我们报告了与肠杆菌科相关的稳健的分类和功能微生物组特征，这些特征与 15 年随访期间的死亡率风险相关。我们的结果扩展了以前的横断面研究，并有助于为研究人类肠道微生物组组成、发病结果和一般健康状况之间的长期关联奠定基础。
