Department of Oncology and Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Department of Nursing, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
J Altern Complement Med. 2021 Sep;27(9):750-759. doi: 10.1089/acm.2020.0531. Epub 2021 May 12.
This study evaluated the effects of a Chinese traditional exercise-monkey frolic in Wuqinxi on depression and quality of life in patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression. In this prospective, randomized-controlled clinical trial, 80 patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression were randomized to an intervention group or a control group. Participants in the intervention group participated in exercise five sessions each week and also received conventional treatment for 4 weeks; whereas participants in the control group received conventional treatment only. The primary outcome was the change in depressive symptoms as obtained through the Self-Rating Depression Scale. Automatic negative thoughts and quality of life were measured by the Automatic Thoughts Questionnaire and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-core30, respectively. Analyses were based on analysis of covariance (ANCOVA) with the "intention-to-treat" population, defined as all randomized patients by imputing mean of the column in place of missing data. Seventy-nine participants (98.8%) completed the study, 40 in the intervention group and 39 in the control group. Results of ANCOVA revealed that, compared with the control group, the intervention group reported significantly lower depression scores, fewer negative thoughts, and showed significant improvement in global health status and physical, role, emotional, cognitive, and social functions ( < 0.05) following the intervention. Post-treatment scores for all symptoms in the intervention group were significantly lower than those in the control group ( < 0.05), except for financial difficulties. No significant differences between the two groups were present in the adverse events (all > 0.05). exercise may be useful for relieving depression, reducing negative thoughts, and improving the quality of life in patients with gastrointestinal cancer undergoing chemotherapy. Clinical Trial Registry (#ChiCTR2100043417).
这项研究评估了中国传统的五禽戏锻炼对化疗期间胃肠道癌症高抑郁风险患者的抑郁和生活质量的影响。在这项前瞻性、随机对照临床试验中，将 80 名胃肠道癌症化疗且有高抑郁风险的患者随机分为干预组和对照组。干预组的参与者每周参加 5 次锻炼，同时接受常规治疗 4 周；而对照组的参与者仅接受常规治疗。主要结局是通过自评抑郁量表评估抑郁症状的变化。自动消极思维和生活质量分别通过自动思维问卷和欧洲癌症研究和治疗组织核心 30 生活质量问卷进行测量。分析基于协方差分析（ANCOVA），以“意向治疗”人群为基础，通过对缺失数据列的平均值进行插补来定义所有随机患者。79 名参与者（98.8%）完成了研究，干预组 40 名，对照组 39 名。ANCOVA 的结果表明，与对照组相比，干预组报告的抑郁评分显著降低，消极思维减少，干预后总体健康状况以及身体、角色、情绪、认知和社会功能显著改善（ < 0.05）。干预后，干预组的所有症状的治疗后评分均显著低于对照组（ < 0.05），除经济困难外。两组间的不良反应无显著差异（均 > 0.05）。五禽戏锻炼可能有助于缓解胃肠道癌症化疗患者的抑郁，减少消极思维，提高生活质量。临床试验注册号（ChiCTR2100043417）。
