Department of Cancer Center, First Hospital of Jilin University, Changchun 130000, China.
Department of Anorectal, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
J Immunol Res. 2021 Apr 24;2021:5556659. doi: 10.1155/2021/5556659. eCollection 2021.
Camptothecin (CPT) is a cytotoxic quinoline alkaloid isolated from the bark and branches of the Chinese tree . CPT inhibits topoisomerase I. It possesses various antitumor activities and is mainly used in the treatment of colon, ovarian, liver, and bone cancers as well as leukemia. CPT inhibits the expressions of inflammatory genes and can prevent death from chronic inflammation. Therefore, we investigated the effect of CPT treatment in ulcerative colitis (UC) using DSS-induced UC mouse model; after that, we explored its potential mechanisms. Here, we found that CPT exerted protection on DSS-induced UC in rats. In addition, the administration prominently reduced the disease activity index as well as colon length of the model rats and remarkably reduced the inflammatory cytokines. Further, CPT significantly reduced several vital proinflammatory proteins in LPS-induced RAW264.7 cells. In summary, our findings demonstrate that CPT is hopefully to act as a therapeutic agent for UC.
喜树碱（CPT）是一种从中国树木的树皮和树枝中分离出来的细胞毒性喹啉生物碱。CPT 抑制拓扑异构酶 I。它具有多种抗肿瘤活性，主要用于治疗结肠癌、卵巢癌、肝癌和骨癌以及白血病。CPT 抑制炎症基因的表达，可预防慢性炎症导致的死亡。因此，我们使用 DSS 诱导的 UC 小鼠模型研究了 CPT 治疗溃疡性结肠炎（UC）的效果，并探讨了其潜在机制。在这里，我们发现 CPT 对 DSS 诱导的大鼠 UC 具有保护作用。此外，该给药方案显著降低了模型大鼠的疾病活动指数和结肠长度，并显著降低了炎症细胞因子。此外，CPT 显著降低了 LPS 诱导的 RAW264.7 细胞中几种重要的促炎蛋白。总之，我们的研究结果表明 CPT 有望成为 UC 的治疗药物。
