Sultan A M
Department of Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Mol Cell Biochem. 1988 Feb;79(2):113-8. doi: 10.1007/BF02424552.
The utilization of D-3-HB and the production of acetoacetate by the perfused rat heart were investigated over a wide range of DL-3-HB concentrations. The rate of D-3-HB utilization is concentration dependent, and shows saturation kinetics. The oxidized amount of D-3-HB when D-3-HB as a sole substrate, accounts at a maximum for 50% of the total oxygen consumption, which suggest the contribution of the endogenous substrate as fuel source along with D-3-HB. The proportion of the D-3-HB consumed that is oxidized rather than released as acetoacetate increases from 70% to 93% as the concentration of D-3-HB falls from 6.99 mM to 0.30 mM.
在很宽的DL-3-羟基丁酸（DL-3-HB）浓度范围内，研究了灌注大鼠心脏对D-3-羟基丁酸（D-3-HB）的利用情况以及乙酰乙酸的生成情况。D-3-HB的利用速率取决于浓度，并呈现出饱和动力学。当D-3-HB作为唯一底物时，其氧化量最多占总耗氧量的50%，这表明内源性底物与D-3-HB一起作为燃料来源发挥作用。随着D-3-HB浓度从6.99 mM降至0.30 mM，被氧化而非以乙酰乙酸形式释放的D-3-HB消耗比例从70%增加到93%。
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