Institute for Lung Research, Philipps-University, Marburg, Germany.
German Center for Lung Research, Giessen, Germany.
Wiley Interdiscip Rev RNA. 2021 Nov;12(6):e1664. doi: 10.1002/wrna.1664. Epub 2021 May 14.
Infectious and inflammatory diseases remain major causes of mortality and morbidity worldwide. To combat bacterial infections, the mammalian immune system employs a myriad of regulators, which secure the effective initiation of inflammatory responses while preventing pathologies due to overshooting immunity. Recently, the human genome has been shown to be pervasively transcribed and to generate thousands of still poorly characterized long noncoding RNAs (lncRNAs). A growing body of literature suggests that lncRNAs play important roles in the regulatory circuitries controlling innate and adaptive immune responses to bacterial pathogens. This review provides an overview of the roles of lncRNAs in the interaction of human and rodent host cells with bacterial pathogens. Further decoding of the lncRNA networks that underlie pathological inflammation and immune subversion could provide new insights into the host cell mechanisms and microbial strategies that determine the outcome of bacterial infections. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.
传染性和炎症性疾病仍然是全球范围内主要的死亡和发病原因。为了对抗细菌感染，哺乳动物免疫系统采用了大量的调节剂，这些调节剂可确保有效启动炎症反应，同时防止因免疫过度而引发的病理。最近，人类基因组被证明是广泛转录的，并产生了数千种仍未得到充分描述的长非编码 RNA（lncRNA）。越来越多的文献表明，lncRNA 在控制先天和适应性免疫反应细菌病原体的调控回路中发挥重要作用。这篇综述概述了 lncRNA 在人与啮齿动物宿主细胞与细菌病原体相互作用中的作用。进一步解码lncRNA 网络，这些网络是病理性炎症和免疫颠覆的基础，可以深入了解宿主细胞机制和微生物策略，这些机制和策略决定了细菌感染的结果。本文属于以下分类：RNA 在疾病与发展中的作用 > RNA 在疾病中的作用 RNA 与蛋白质和其他分子的相互作用 > 蛋白质-RNA 相互作用：功能意义。
