The Chemours Company, Wilmington, Delaware, USA.
BeachEdge Consulting, Media, Pennsylvania, USA.
Integr Environ Assess Manag. 2021 Sep;17(5):1045-1055. doi: 10.1002/ieam.4450. Epub 2021 Jun 22.
Per- and poly-fluoroalkyl substances (PFAS) are a universe of fluorinated organic substances with very different physical, chemical, and biological properties including polymers and non-polymers; solids, liquids, and gases. Commercial PFAS-based products have been used in a wide variety of industrial and consumer applications because they have unique performance properties of significant socioeconomic value. The PFAS definition has evolved and expanded over the years. Numerous lists of PFAS, some with thousands of entries, have been compiled, but none have clearly identified which of the substances are commercially relevant. This study is the first to use a bona-fide "bottom up" approach to identify how many of the 4730 PFAS substances listed in a 2018 OECD/UNEP Report are directly connected to commercial products based on input from three major global producers. This study provides new and valuable insight into the 2018 OECD/UNEP Report list of PFAS substances. The results show that 256, less than 6%, of the 4730 PFAS substances presented in the 2018 OECD/UNEP Report are commercially relevant globally. This study suggests that grouping and categorizing PFAS using fundamental classification criteria based on composition and structure can be used to identify appropriate groups of PFAS substances for risk assessment, thereby dispelling assertions that there are too many PFAS chemistries to conduct proper regulatory risk assessments for the commercially relevant substances. Integr Environ Assess Manag 2021;17:1045-1055. © 2021 The Chemours Company, Beach Edge Consulting, LLC, AGC Chemicals Americas Inc., Daikin America Inc. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
全氟和多氟烷基物质（PFAS）是一个由具有非常不同物理、化学和生物特性的氟化有机物质组成的宇宙，包括聚合物和非聚合物；固体、液体和气体。由于具有具有重大社会经济价值的独特性能，商用 PFAS 基产品已被广泛应用于各种工业和消费应用。PFAS 的定义多年来一直在演变和扩展。已经编制了许多 PFAS 清单，其中一些包含数千个条目，但没有一个明确指出哪些物质具有商业相关性。本研究首次使用真正的“自下而上”方法，根据来自三大全球生产商的信息，确定在 2018 年经合组织/环境署报告中列出的 4730 种 PFAS 物质中有多少种直接与商业产品相关。本研究为 2018 年经合组织/环境署报告中 PFAS 物质清单提供了新的有价值的见解。结果表明，在 2018 年经合组织/环境署报告中列出的 4730 种 PFAS 物质中，有 256 种，不到 6%，在全球范围内具有商业相关性。本研究表明，使用基于组成和结构的基本分类标准对 PFAS 进行分组和分类，可以用于识别适当的 PFAS 物质组进行风险评估，从而消除了认为有太多 PFAS 化学物质而无法对商业相关物质进行适当的监管风险评估的说法。2021 年，《综合环境评估与管理》由威利期刊公司（Wiley Periodicals LLC）代表环境毒理与化学学会（SETAC）出版。
