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识别免疫相关长链非编码 RNA 对预测头颈部鳞状细胞癌的预后和免疫治疗反应的作用。

Identification of Immune-Related LncRNA Pairs for Predicting Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma.

机构信息

Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

Department of Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.

出版信息

Front Immunol. 2021 Apr 29;12:658631. doi: 10.3389/fimmu.2021.658631. eCollection 2021.

DOI:10.3389/fimmu.2021.658631
PMID:33995377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8116744/
Abstract

Long noncoding RNAs (lncRNAs) have multiple functions with regard to the cancer immunity response and the tumor microenvironment. The prognosis of head and neck squamous cell carcinoma (HNSCC) is still poor currently, and it may be effective to predict the clinical outcome and immunotherapeutic response of HNSCC by immunogenic analysis. Therefore, by using univariate COX analysis and Lasso Cox regression, we identified a signature consisting of 21 immune-related lncRNA pairs (IRLPs) that predicted clinical outcome and Immunotherapeutic response in HNSCC. Specifically, it was associated with immune cell infiltration (i.e., T cells CD4 memory resting, CD8 T cells, macrophages M0, M2, and NK cells), and more importantly this signature was strongly related with immune checkpoint inhibitors (ICIs) [such as PDCD1 (r = -0.35, P < 0.001), CTLA4 (r = -0.26, P < 0.001), LAG3 (r = -0.22, P < 0.001) and HAVCR2 (r = -0.2, P < 0.001)] and immunotherapy-related biomarkers (MMR and HLA). The present study highlighted the value of the 21 IRLPs signature as a predictor of prognosis and immunotherapeutic response in HNSCC.

摘要

长链非编码 RNA（lncRNAs）在癌症免疫反应和肿瘤微环境中具有多种功能。目前，头颈部鳞状细胞癌（HNSCC）的预后仍然较差，通过免疫原性分析预测 HNSCC 的临床结局和免疫治疗反应可能是有效的。因此，我们通过单变量 COX 分析和 Lasso Cox 回归，确定了由 21 个免疫相关 lncRNA 对（IRLPs）组成的特征，该特征可预测 HNSCC 的临床结局和免疫治疗反应。具体而言，它与免疫细胞浸润（即 CD4 记忆静止 T 细胞、CD8 T 细胞、M0、M2 巨噬细胞和 NK 细胞）有关，更重要的是，该特征与免疫检查点抑制剂（ICIs）[如 PDCD1（r = -0.35，P < 0.001）、CTLA4（r = -0.26，P < 0.001）、LAG3（r = -0.22，P < 0.001）和 HAVCR2（r = -0.2，P < 0.001）]和免疫治疗相关生物标志物（MMR 和 HLA）密切相关。本研究强调了 21 个 IRLPs 特征作为预测 HNSCC 预后和免疫治疗反应的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/261dbb178d65/fimmu-12-658631-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/67cecff102f0/fimmu-12-658631-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/9b52be4ec6b7/fimmu-12-658631-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/46ee235cad69/fimmu-12-658631-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/9c9d1393c453/fimmu-12-658631-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/261dbb178d65/fimmu-12-658631-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/a06839016d26/fimmu-12-658631-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/f273edb3bb58/fimmu-12-658631-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/67cecff102f0/fimmu-12-658631-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/46ee235cad69/fimmu-12-658631-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/9c9d1393c453/fimmu-12-658631-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c2cf/8116744/261dbb178d65/fimmu-12-658631-g007.jpg

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