Kadkhodaeian Hamid Aboutaleb
Nervous System Stem Cell Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Basic Clin Neurosci. 2021 Jan-Feb;12(1):29-42. doi: 10.32598/bcn.9.10.510. Epub 2021 Jan 1.
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host cells but control the process. Today, transcription factors required for retinal progenitor cells are well known, but the generation of these cells from mesenchymal stem cells is an ideal goal. The purpose of the paper is to review novel methods for retinal progenitor cell production and selecting a set of signaling molecules in the presence of adult retinal pigment epithelium and extraocular mesenchyme acting as inducers of retinal cell differentiation.
几种信号通路和转录因子在细胞的体外发育和分化过程中控制细胞命运。这些因子的协同作用导致细胞特化。在共培养方法中，许多此类因子由宿主细胞分泌，但控制着这一过程。如今，视网膜祖细胞所需的转录因子已为人熟知，但从间充质干细胞生成这些细胞是一个理想目标。本文的目的是综述视网膜祖细胞产生的新方法，以及在成年视网膜色素上皮和眼外间充质作为视网膜细胞分化诱导剂存在的情况下选择一组信号分子。
