INSERM, Laboratory of Integrative Cancer Immunology, Paris, France.
Equipe Labellisée Ligue Contre Le Cancer, Paris, France.
Oncoimmunology. 2021 Apr 25;10(1):1912250. doi: 10.1080/2162402X.2021.1912250.
Early intervention and risk stratification solutions for lung cancer are limited by our understanding of how carcinogenesis transforms the pre-invasive epithelium and its microenvironment before the carcinoma stage. We describe the sequence of molecular and cellular changes leading to cancer formation and the co-evolution of the earliest immune response. We revealed that immune sensing, infiltration and activation of immune cells, immune escape, and microenvironment reorganization occur early in pre-cancer. These findings urge the need for broadening the scope of the established immunotherapy approaches toward prophylactic cancer treatment and preventive intervention. Leveraging the immune contexture and the mechanisms of immune modulation for individuals at risk of developing cancer and further to the general population will allow for early detection, chemoprevention, and risk stratification in the near future.
早期干预和肺癌风险分层解决方案受到我们对致癌作用如何在癌前阶段之前改变侵袭前上皮及其微环境的理解的限制。我们描述了导致癌症形成的分子和细胞变化的顺序以及最早的免疫反应的共同进化。我们揭示了免疫感应、免疫细胞的浸润和激活、免疫逃逸以及微环境重组成分在癌前阶段很早就发生了。这些发现促使我们拓宽既定免疫治疗方法的范围，将其应用于预防性癌症治疗和预防干预。利用免疫结构和免疫调节机制，针对有患癌症风险的个体，进一步针对普通人群，将在不久的将来实现早期检测、化学预防和风险分层。
