Dietl Beatriz, Henares Desirée, Boix-Palop Lucía, Muñoz-Almagro Carmen, Garau Javier, Calbo Esther
Infectious Diseases Unit, Hospital Universitari Mútua Terrassa, Terrassa, Spain.
Department of Medicine, Universitat Internacional de Catalunya, Barcelona, Spain.
Front Med (Lausanne). 2021 Apr 20;8:650271. doi: 10.3389/fmed.2021.650271. eCollection 2021.
Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. might colonize the upper respiratory tract and is the main aetiological agent of community-acquired pneumonia (CAP). In the last decades, several factors related to the host, the microorganism and the antibiotic therapy have been investigated to identify risk factors associated with the development of invasive pneumococcal disease (IPD). Nevertheless, these factors themselves do not explain the risk of developing disease or its severity. Recently, some studies have focused on the importance of nasopharyngeal (NP) microbiome and its relation to respiratory health. This review presents existing evidence of the potential role of NP microbiome in the development of IPD.
下呼吸道感染，如肺炎，是全球主要死因之一。（原文此处表述有误，缺少主语，推测可能是某种细菌，暂按“它”翻译）它可能定植于上呼吸道，是社区获得性肺炎（CAP）的主要病原体。在过去几十年中，人们对与宿主、微生物和抗生素治疗相关的几个因素进行了研究，以确定与侵袭性肺炎球菌疾病（IPD）发生相关的危险因素。然而，这些因素本身并不能解释发病风险或疾病的严重程度。最近，一些研究聚焦于鼻咽（NP）微生物群的重要性及其与呼吸健康的关系。本综述介绍了NP微生物群在IPD发生中潜在作用的现有证据。
