益生菌和白藜芦醇可使糖尿病大鼠肠道中的胰高血糖素样肽-1水平及氧化应激恢复正常。
Probiotic and resveratrol normalize GLP-1 levels and oxidative stress in the intestine of diabetic rats.
作者信息
Pegah Atefeh, Abbasi-Oshaghi Ebrahim, Khodadadi Iraj, Mirzaei Fatemeh, Tayebinai Heidar
机构信息
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Metabol Open. 2021 Apr 15;10:100093. doi: 10.1016/j.metop.2021.100093. eCollection 2021 Jun.
BACKGROUND
Recently, the use of incretins has been considered as a therapeutic target for diabetes. One of the important incretins in the improvement of diabetes is glucagon-like peptide (GLP-1), which is secreted by the gut and reduces the apoptosis of pancreatic β-cells and improves insulin sensitivity. In this experiment we determined the effects of resveratrol and probiotics on insulin resistance, oxidative stress, and GLP-1 in type 2 diabetes (T2D) rats.
METHODS
In this study, 40 male Wistar male rats were divided into 5 groups: 1. Control group, 2. T2D, 3. T2D treated with probiotics, 4. T2D treated with resveratrol, 5. T2D group treated with probiotics and resveratrol. After four weeks, the intestine were removed for histopathological analysis, biochemical tests, and oxidative stress markers.
RESULTS
Probiotics and resveratrol significantly decreased (p < 0.001) glucose and insulin resistance, and increased (p < 0.001) GLP1 and total antioxidant capacity compared to the diabetic group. Treatment with probiotics and resveratrol also returned intestinal histological changes in diabetic rats to normal.
CONCLUSION
Resveratrol and probiotics appear to be effective in controlling T2D by increasing GLP-1 levels and reducing oxidative stress.
背景
最近，肠促胰岛素的应用被认为是糖尿病的一个治疗靶点。在改善糖尿病方面重要的肠促胰岛素之一是胰高血糖素样肽（GLP-1），它由肠道分泌，可减少胰腺β细胞的凋亡并提高胰岛素敏感性。在本实验中，我们测定了白藜芦醇和益生菌对2型糖尿病（T2D）大鼠胰岛素抵抗、氧化应激和GLP-1的影响。
方法
在本研究中，40只雄性Wistar大鼠被分为5组：1. 对照组，2. T2D组，3. 用益生菌治疗的T2D组，4. 用白藜芦醇治疗的T2D组，5. 用益生菌和白藜芦醇治疗的T2D组。四周后，取出肠道进行组织病理学分析、生化检测和氧化应激标志物检测。
结果
与糖尿病组相比，益生菌和白藜芦醇显著降低了（p < 0.001）血糖和胰岛素抵抗，并提高了（p < 0.001）GLP1和总抗氧化能力。用益生菌和白藜芦醇治疗还使糖尿病大鼠的肠道组织学变化恢复正常。
结论
白藜芦醇和益生菌似乎通过提高GLP-1水平和减少氧化应激来有效控制T2D。
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