光生物调节增强轻度认知障碍老年人的记忆处理：一项功能近红外光谱研究。

Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy Study.

机构信息

Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China.

Research Centre for Neuropsychological Well-Being, The Chinese University of Hong Kong, China.

出版信息

J Alzheimers Dis. 2021;83(4):1471-1480. doi: 10.3233/JAD-201600.

DOI:10.3233/JAD-201600

PMID:33998541

Abstract

BACKGROUND

Recent studies of photobiomodulation (PBM) in patients with cognitive or psychological disorders (including traumatic brain injury, stroke, and dementia) have yielded some encouraging results.

OBJECTIVE

In this study, we aimed to investigate the effect of a single stimulation on memory in older adults with mild cognitive impairment (MCI).

METHODS

After PBM, hemodynamic changes, as a measure of functional brain activity, were evaluated using functional near-infrared spectroscopy (fNIRS). Eighteen subjects who met the criteria of MCI were randomly assigned to control and experimental groups. A single real or sham PBM session was administered to the forehead of each patient in the experimental and control groups, respectively. All subjects performed a visual memory span test before and after the stimulation, and their hemodynamic responses during the tasks were measured using fNIRS.

RESULTS

The results showed that among the MCI subjects, only those who received PBM, but not those who received the sham stimulation, demonstrated significant improvement in the visual memory performance and a reduction in the hemodynamic response during the tasks.

CONCLUSION

These findings suggest that PBM may reduce the cognitive efforts needed to complete tasks that require high memory loads, and thus improve the cognitive performance of individuals with MCI.

摘要

背景

最近对认知或心理障碍（包括创伤性脑损伤、中风和痴呆症）患者的光生物调节（PBM）研究取得了一些令人鼓舞的结果。

目的

本研究旨在探讨单次刺激对轻度认知障碍（MCI）老年人记忆的影响。

方法

在 PBM 之后，使用功能近红外光谱（fNIRS）评估作为功能性大脑活动测量的血液动力学变化。符合 MCI 标准的 18 名受试者被随机分配到对照组和实验组。在实验组和对照组中，分别对每位患者的前额进行单次真实或假 PBM 治疗。所有受试者在刺激前后均进行视觉记忆广度测试，并使用 fNIRS 测量任务期间的血液动力学反应。