严重急性呼吸综合征冠状病毒2型快速抗原检测的阴暗面：筛查无症状患者。
The dark side of SARS-CoV-2 rapid antigen testing: screening asymptomatic patients.
作者信息
Caruana G, Lebrun L-L, Aebischer O, Opota O, Urbano L, de Rham M, Marchetti O, Greub G
机构信息
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Switzerland.
Patients Safety Program, Ensemble Hospitalier de la Côte (EHC), Morges, Switzerland.
出版信息
New Microbes New Infect. 2021 Jul;42:100899. doi: 10.1016/j.nmni.2021.100899. Epub 2021 May 14.
Abstract
Several reports showed SARS-CoV-2 rapid antigen tests (RATs) performances among COVID-19 symptomatic subjects in outpatient settings during periods of highest incidence of infections and high rates of hospital admissions, but few data are present for asymptomatic patients. We investigated the role of RATs in an emergency department, as a novel screening tool before admission for COVID-19 asymptomatic patients. A total of 116 patients were screened on admission in a 250-bed community hospital in Morges, Switzerland. RAT detected 2/7 RT-PCR-positive patients and delivered two false-positive results. These data suggest the non-fiability of RATs screening in this clinical scenario.
摘要
几份报告显示了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）快速抗原检测（RATs）在门诊环境中新冠病毒疾病（COVID-19）有症状患者中的表现，这些时期感染发病率最高且住院率很高，但无症状患者的数据很少。我们调查了RATs在急诊科的作用，作为COVID-19无症状患者入院前的一种新型筛查工具。在瑞士莫尔日一家拥有250张床位的社区医院，共有116名患者在入院时接受了筛查。RAT检测出2/7例逆转录聚合酶链反应（RT-PCR）阳性患者，并给出了两个假阳性结果。这些数据表明在这种临床情况下RATs筛查不可靠。
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3
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