Rolfe P F, Boray J C
University of Sydney, Department of Veterinary Pathology, New South Wales.
Aust Vet J. 1988 May;65(5):148-50. doi: 10.1111/j.1751-0813.1988.tb14443.x.
Controlled trials were used to assess the efficacy of various anthelmintics against immature and adult paramphistomes in 75 experimentally or naturally infected sheep. Albendazole (20 mg/kg), praziquantel (10 mg/kg), nitroxynil (10 mg/kg) triclabendazole (10 and 100 mg/kg), profenophos (25 mg/kg) and netobimin (15 mg/kg) had little or no activity against adult or immature fluke. Niclosamide at 100 mg/kg had high efficacy (99%) against intestinal fluke but none against adult fluke. A 2- tertiary-butyl benzthiazole compound (CGA 72630) at 25 mg/kg and resorantel at 65 mg/kg had very high efficacy against both adult and immature fluke in the rumen and small intestine respectively. The efficacy of other anthelmintics which have been used against paramphistomes in sheep is reviewed.
采用对照试验评估了多种驱虫药对75只实验感染或自然感染绵羊体内未成熟和成熟双口吸虫的疗效。阿苯达唑（20毫克/千克）、吡喹酮（10毫克/千克）、硝氯酚（10毫克/千克）、三氯苯达唑（10和100毫克/千克）、丙溴磷（25毫克/千克）和奈托比明（15毫克/千克）对成虫或未成熟吸虫几乎没有活性。100毫克/千克的氯硝柳胺对肠道吸虫有高效（99%），但对成虫吸虫无效。一种2-叔丁基苯并噻唑化合物（CGA 72630），剂量为25毫克/千克，雷琐太尔剂量为65毫克/千克，分别对瘤胃和小肠中的成虫和未成熟吸虫有非常高的疗效。本文综述了其他已用于绵羊双口吸虫病防治的驱虫药的疗效。
