Netherlands Cancer Institute, Oncode Institute, Division of Molecular Pathology, Plesmanlaan 121, 1066CX, Amsterdam, the Netherlands.
VIB-KULeuven Center for Cancer Biology, Herestraat 49, 3000, Leuven, Belgium.
Curr Opin Cell Biol. 2021 Oct;72:28-35. doi: 10.1016/j.ceb.2021.04.004. Epub 2021 May 18.
Microenvironmental cues in tumors induce in a wide variety of cellular states that subsequently lead to cancer cells with distinct cellular identity, behavior, and fate. Recent literature suggests that the ability to change cellular states, a process defined as cell state plasticity, enable cells to rapidly adapt to their changing environment during tumor progression and metastasis. In this review, we will discuss how recent high-resolution intravital microscopy studies have been instrumental to reveal the real-time dynamics of tumor cell state plasticity during the different steps of the metastatic cascade. In addition, we will highlight the role of tumor plasticity during anticancer treatment response, and how plasticity can be used as a potential druggable target.
肿瘤中的微环境线索诱导广泛的细胞状态，进而导致具有不同细胞特征、行为和命运的癌细胞。最近的文献表明，改变细胞状态的能力，即细胞状态可塑性过程，使细胞能够在肿瘤进展和转移过程中快速适应其不断变化的环境。在这篇综述中，我们将讨论最近的高分辨率活体显微镜研究如何有助于揭示转移级联的不同步骤中肿瘤细胞状态可塑性的实时动态。此外，我们将强调肿瘤可塑性在抗癌治疗反应中的作用，以及可塑性如何可用作潜在的可治疗靶点。
