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用于牙周递送盐酸多西环素的生物陶瓷负载微球的制备及设计辅助质量（Qb-d）优化

Preparation and quality by design assisted (Qb-d) optimization of bioceramic loaded microspheres for periodontal delivery of doxycycline hyclate.

作者信息

Jain Pooja, Garg Abhinav, Farooq Uzma, Panda Amulya K, Mirza Mohd Aamir, Noureldeen Ahmed, Darwish Hadeer, Iqbal Zeenat

机构信息

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Product Development Cell, National Institute of Immunology, New Delhi, India.

出版信息

Saudi J Biol Sci. 2021 May;28(5):2677-2685. doi: 10.1016/j.sjbs.2021.03.046. Epub 2021 Mar 21.

DOI:10.1016/j.sjbs.2021.03.046
PMID:34025152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117247/
Abstract

PLGA (Lactic- co-glycolic acid) coated chitosan microspheres loaded with hydroxyapatite and doxycycline hyclate complex were developed in the present study for periodontal delivery. A modified single emulsion method was adopted for the development of microspheres. Formulation was optimized on the basis of particle size, drug loading and encapsulation efficiency with the central composite design using 2 factorial design. Microspheres were optimized and electron microscopy revealed their spherical shape and porous nature. study showed initial burst and then sustained release behavior of the formulation for 14 days. Further, antibacterial study performed on E. coli (ATCC-25922) and S. aureus (ATCC-29213) revealed concentration dependent activity. Also, cyto-toxicity assessment ensures biocompatibility of the formulation with the fibroblast's cells. Overall, the quality by design assisted PLGA microspheres, demonstrated the desired attributes and were found suitable for periodontal drug delivery.

摘要

在本研究中，开发了负载羟基磷灰石和盐酸多西环素复合物的聚乳酸-乙醇酸共聚物（PLGA）包被的壳聚糖微球用于牙周给药。采用改良的单乳液法制备微球。基于粒径、载药量和包封率，采用二因素中心复合设计对制剂进行优化。对微球进行了优化，电子显微镜显示其呈球形且具有多孔性质。研究表明该制剂具有初始突释然后持续14天的释放行为。此外，对大肠杆菌（ATCC - 25922）和金黄色葡萄球菌（ATCC - 29213）进行的抗菌研究显示出浓度依赖性活性。同时，细胞毒性评估确保了该制剂与成纤维细胞的生物相容性。总体而言，质量源于设计辅助的PLGA微球展现出所需特性，被发现适用于牙周药物递送。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/df4cd0c0c9c9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/d671e8292ec8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/c2346943b6be/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/950c0700dceb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/180c133b4c33/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/3e9e3e5c2310/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/df4cd0c0c9c9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/d671e8292ec8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/c2346943b6be/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/950c0700dceb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/180c133b4c33/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/3e9e3e5c2310/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/effa/8117247/df4cd0c0c9c9/gr6.jpg

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2
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J Liposome Res. 2021 Dec;31(4):381-388. doi: 10.1080/08982104.2020.1849279. Epub 2020 Nov 19.
3
A 4-D approach for amelioration of periodontitis.
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Pharmaceutics. 2024 Jan 16;16(1):115. doi: 10.3390/pharmaceutics16010115.
4
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Nanoscale Adv. 2024 Jan 3;6(2):648-668. doi: 10.1039/d3na00943b. eCollection 2024 Jan 16.
5
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Bioengineering (Basel). 2023 Mar 13;10(3):354. doi: 10.3390/bioengineering10030354.
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8
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10
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