Jain Pooja, Mirza Mohd Aamir, Talegaonkar Sushama, Nandy Shyamasree, Dudeja Mridu, Sharma Nilima, Anwer Md Khalid, Alshahrani Saad M, Iqbal Zeenat
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard New Delhi 110062 India
Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Govt. of NCT of Delhi New Delhi India.
RSC Adv. 2020 Feb 27;10(14):8530-8538. doi: 10.1039/c9ra09569a. eCollection 2020 Feb 24.
In the current work, we set out to develop and evaluate a gingiva disc of cellulose acetate phthalate and poloxamer F-127 for the simultaneous delivery of multiple drugs, namely minocycline, celecoxib, doxycycline hyclate, and simvastatin, to abolish infection, impede inflammation, avert collagen destruction, and promote alveolar bone regeneration, respectively. release studies revealed the sustained release profiles of the drugs for 12 h and that they were active against , and The bioactivity levels of these drugs were assessed by comparing the number of colony forming units during different phases of a study on Wistar rats, and the results showed a reduction in the number of bacterial colonies with the applied formulation. A mucosal irritation study conducted on Wistar rat gingiva confirmed the non-irritancy of the optimal gingiva disc. Hence, this customized, non-invasive polymeric gingiva disc displaying a sustained release of drugs can be a useful tool to treat acute to moderate stages of periodontitis.
在当前的工作中，我们着手研发并评估一种由邻苯二甲酸醋酸纤维素和泊洛沙姆F - 127制成的牙龈盘，用于同时递送多种药物，即米诺环素、塞来昔布、盐酸多西环素和辛伐他汀，分别用于消除感染、抑制炎症、防止胶原蛋白破坏以及促进牙槽骨再生。释放研究表明这些药物具有12小时的持续释放曲线，并且它们对……、……和……具有活性。通过比较在对Wistar大鼠进行的一项研究的不同阶段的菌落形成单位数量来评估这些药物的生物活性水平，结果显示使用该制剂后细菌菌落数量减少。在Wistar大鼠牙龈上进行的黏膜刺激性研究证实了最佳牙龈盘无刺激性。因此，这种定制的、非侵入性的、能持续释放药物的聚合物牙龈盘可成为治疗急性至中度牙周炎阶段的有用工具。
