Gero PTE, Singapore, Singapore.
Skolkovo Institute of Science and Technology, Moscow, Russia.
Nat Commun. 2021 May 25;12(1):2765. doi: 10.1038/s41467-021-23014-1.
We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of the aging process, henceforth referred to as dynamic organism state indicator (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 - 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.
我们研究了在一个大型消费者诊断实验室的 CBC 测量纵向数据库中，个体衰老轨迹上的生物体状态波动的动态特性。为了简化分析，我们使用了来自 CBC 变量的对数线性死亡率估计作为衰老过程的单一定量指标，此后称为动态生物体状态指标（DOSI）。我们观察到，年龄相关的人口 DOSI 分布变宽可以通过 DOSI 自相关时间测量的生理弹性逐渐丧失来解释。对这一趋势的推断表明，DOSI 的恢复时间和方差将在 120-150 岁的临界点同时发散，这对应于完全丧失弹性。这一观察结果立即得到了通过可穿戴设备收集的日间体力活动水平波动的相关特性的独立分析的证实。我们的结论是，导致生命终结的临界点是生物体的内在生物学特性，它独立于应激因素，标志着人类寿命的基本或绝对极限。
