Alavi Afsaneh, Archer Jeannine, Coutts Patricia
Division of Dermatology, University of Toronto, Toronto, ON, Canada.
Mayo Clinic, Rochester, MN, USA.
SAGE Open Med Case Rep. 2021 May 13;9:2050313X211013684. doi: 10.1177/2050313X211013684. eCollection 2021.
The objective of this case series was to assess the wound healing effectiveness of a collagen matrix wound dressing containing partially denatured collagen, carboxymethyl cellulose, alginate and ethylenediaminetetraacetic acid in chronic lower extremity ulcers. A total of nine patients with refractory lower extremity ulcers were treated with the collagen contact layer in addition to standard of care. Wound healing progress was measured at 2, 4 and 8 weeks. An average decrease in wound size of 73% was achieved across patients at week 8, with complete healing in two patients. The intervention was easy to use and well tolerated by patients. The results of this study, although preliminary, suggest that the advanced collagen matrix dressing represents an effective and safe treatment strategy for healing refractory chronic lower extremity ulcers of varying etiologies. Further investigation is needed to evaluate efficacy in a larger randomized clinical trial with focus on cost-effectiveness and impact on patient's quality-of-life.
本病例系列的目的是评估一种含有部分变性胶原蛋白、羧甲基纤维素、藻酸盐和乙二胺四乙酸的胶原蛋白基质伤口敷料对慢性下肢溃疡的伤口愈合效果。除标准护理外，共有9例难治性下肢溃疡患者接受了胶原蛋白接触层治疗。在第2、4和8周测量伤口愈合进展。第8周时，患者伤口大小平均减少73%，两名患者完全愈合。该干预措施使用方便，患者耐受性良好。本研究结果虽为初步结果，但表明这种先进的胶原蛋白基质敷料是治疗各种病因引起的难治性慢性下肢溃疡的一种有效且安全的治疗策略。需要进一步研究以在更大规模的随机临床试验中评估其疗效，重点关注成本效益以及对患者生活质量的影响。
